Gene: CDH7
Official Full Name: cadherin 7provided by HGNC
Gene Summary: This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types. Mutations in this gene may be associated with bipolar disease in human patients. This gene is present in a gene cluster on chromosome 18. [provided by RefSeq, May 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38619 | CDH7 Knockout cell line (HEK293) | Human | CDH7 | 1:3~1:6 | Negative | Online Inquiry |
CDH7 Gene Knockout Cell Lines are precisely engineered cellular models that facilitate the study of the cadherin-7 (CDH7) gene, known for its role in cell adhesion and signaling pathways critical for various biological processes, including embryogenesis and tissue morphogenesis. These knockout cell lines have been developed using advanced CRISPR-Cas9 technology, ensuring the targeted deletion of the CDH7 gene, thus allowing researchers to investigate its specific contributions to cellular behavior and disease mechanisms.
The primary functions of CDH7 Gene Knockout Cell Lines include enabling the assessment of altered cellular responses related to cell adhesion, migration, and proliferation when CDH7 is absent. Researchers can elucidate the downstream effects of CDH7 loss, such as its impact on the epithelial-mesenchymal transition (EMT) and the potential implications in cancer metastasis and other pathologies. The ability to manipulate these lines also supports the dissection of compensatory mechanisms cells may employ in response to the gene knockout.
Scientifically, these cell lines hold significant importance in both research and clinical settings. They are vital tools for understanding the molecular dynamics underlying various diseases, particularly those associated with aberrant cell adhesion processes, such as cancer. As potential therapeutic targets, insights derived from CDH7 research could lead to novel intervention strategies or biomarkers.
Compared to conventional cell lines or models, CDH7 Gene Knockout Cell Lines offer enhanced specificity and reliability. With precise genetic modifications, they reduce variability seen in studies utilizing wild-type lines, thereby yielding more consistent and reproducible results. This specificity allows for a more profound exploration of gene function in relevant biological contexts, enhancing the robustness of experimental outcomes.
For researchers and clinicians focused on cell biology, cancer research, or developmental studies, CDH7 Gene Knockout Cell Lines represent an invaluable asset, offering a reliable model for dissecting complex biological systems. The unique attributes of these cell lines empower scientists to pursue innovative research without the constraints that come from using less targeted approaches.
Our company prides itself on its expertise in developing advanced biological products tailored for the research community, and we are committed to providing high-quality tools that drive scientific discovery. By choosing our CDH7 Gene Knockout Cell Lines, customers gain access to cutting-edge resources that stand at the forefront of cell biology research.
Please note that all services are for research use only. Not intended for any clinical use.
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