Home / CDH17 Knockout Cell Lines

CDH17 Knockout Cell Lines

Gene: CDH17

Official Full Name: cadherin 17provided by HGNC

Gene Summary: This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38611 CDH17 Knockout cell line (HEK293) Human CDH17 1:3~1:6 Negative Online Inquiry
KO38612 CDH17 Knockout cell line (A549) Human CDH17 1:3~1:4 Negative Online Inquiry

Background

CDH17 Gene Knockout Cell Lines are advanced cellular models specifically engineered to lack the expression of the cadherin 17 (CDH17) gene, which is predominantly associated with the development of certain types of cancer and neurological conditions. These cell lines serve as critical tools for researchers aiming to investigate the molecular pathways influenced by CDH17, as well as to explore the gene's role in cellular adhesion, signaling, and tumorigenesis.

The key mechanism behind these knockout cell lines involves CRISPR-Cas9 technology, which facilitates precise editing of the genome, leading to the targeted deletion of the CDH17 gene. This genetic alteration enables scientists to study the effects of CDH17 deficiency on cell behavior, such as proliferation, migration, and interaction with other cells. Consequently, these models allow for in-depth exploration of pathological processes and have the potential to unveil new therapeutic targets for conditions driven by aberrant CDH17 expression.

The scientific importance of CDH17 Gene Knockout Cell Lines extends beyond basic research; they hold significant promise in clinical applications, particularly in the development of personalized medicine strategies. By understanding how CDH17 influences disease mechanisms, these cell lines can guide the identification of biomarkers and novel interventions for targeted therapies.

Compared to alternative models, such as wild-type cell lines or other knockout systems that may result in off-target effects, CDH17 Gene Knockout Cell Lines offer a high degree of specificity and reproducibility. This specificity is crucial for yielding reliable data and facilitating the transition from bench to bedside.

For researchers and clinicians alike, the value of these cell lines cannot be overstated. They empower users to glean insights into complex biological systems, refine therapeutic approaches, and ultimately enhance patient outcomes. Our company’s commitment to providing high-quality, rigorously validated biological products ensures that scientists have access to the most reliable tools available for their research endeavors. With our expertise and state-of-the-art offerings, we strive to support the continuum of scientific discovery and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.