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CDH13 Knockout Cell Lines

Gene: CDH13

Official Full Name: cadherin 13provided by HGNC

Gene Summary: This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38610 CDH13 Knockout cell line (HeLa) Human CDH13 1:3~1:6 Negative Online Inquiry

Background

CDH13 Gene Knockout Cell Lines represent an innovative tool in molecular biology, specifically designed to facilitate the study of the cadherin-13 gene (CDH13), which is primarily involved in cell adhesion processes. By utilizing targeted gene editing technologies, these cell lines have been engineered to disrupt the functional expression of the CDH13 gene, allowing researchers to investigate its role in various biological contexts, including cell signaling, tissue morphogenesis, and disease mechanisms.

The primary function of CDH13 Gene Knockout Cell Lines is to provide a controlled experimental platform for detailed examination of cellular processes that rely on cadherin-mediated adhesion. By knocking out the CDH13 gene, scientists can explore its implications in cancer research, cardiovascular diseases, and other conditions where cell-cell interaction is significant. The mechanisms at play can be studied by comparing the behavioral, morphological, and metabolic changes between knockout cells and wild-type counterparts, elucidating the diverse pathways influenced by this adhesion molecule.

In research and clinical settings, these cell lines hold substantial scientific relevance. They can serve as reliable models for understanding how the disruption of CDH13 influences not only cell proliferation but also the invasiveness and metastatic potential of certain cancer types. Their application extends to drug discovery, where they can be utilized to screen therapeutic compounds aimed at re-establishing proper cell adhesion and behavior.

Compared to alternative cell models, CDH13 Gene Knockout Cell Lines offer distinct advantages, including precise genetic modification and reproducibility in experimental outcomes. This specificity allows for more accurate hypothesis testing and the elucidation of causative factors in diseases associated with disrupted cadherin function.

For researchers and clinicians focused on the molecular underpinnings of diseases, these cell lines provide unparalleled value. By enabling targeted inquiries into the roles of CDH13, they facilitate the advancement of knowledge that could lead to innovative therapeutic strategies.

Our company specializes in offering high-quality biological products, backed by extensive research and development expertise. We understand the critical role that precise tools play in advancing scientific inquiry, and we are committed to providing researchers with the resources they need to push the boundaries of discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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