Gene: CDC42BPA
Official Full Name: CDC42 binding protein kinase alphaprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34145 | CDC42BPA Knockout cell line (HeLa) | Human | CDC42BPA | 1:3~1:6 | Negative | Online Inquiry |
KO34146 | CDC42BPA Knockout cell line (HCT 116) | Human | CDC42BPA | 1:2~1:4 | Negative | Online Inquiry |
KO34147 | CDC42BPA Knockout cell line (HEK293) | Human | CDC42BPA | 1:3~1:6 | Negative | Online Inquiry |
KO34148 | CDC42BPA Knockout cell line (A549) | Human | CDC42BPA | 1:3~1:4 | Negative | Online Inquiry |
CDC42BPA Gene Knockout Cell Lines are a specialized set of cellular models designed to facilitate the study of the CDC42 binding protein alpha (Cdc42BPA), a crucial regulator in various cellular processes such as cytoskeletal dynamics, cell migration, and signaling pathways. These knockout cell lines have been meticulously engineered to suppress the expression of the CDC42BPA gene, enabling researchers to investigate its specific roles and the broader implications of its absence on cellular functions.
The primary function of these knockout cell lines lies in their ability to mimic physiological conditions that facilitate the study of Cdc42BPA-related cellular mechanisms. By observing the changes in cell behavior, migration patterns, and signaling cascades devoid of Cdc42BPA, scientists can better understand how alterations in this gene contribute to diseases such as cancer, neurodegenerative conditions, and other disorders where cytoskeletal organization is disrupted. The knockout model allows for more precise experimentation, enabling researchers to dissect the intricate relationships between this protein and other cellular components.
The scientific importance of CDC42BPA Gene Knockout Cell Lines extends beyond fundamental research; they hold significant potential in clinical applications. These models serve as valuable tools for drug development, helping to identify novel therapeutic targets and evaluate drug efficacy within a relevant biological context. Researchers seeking to explore the role of Cdc42BPA in pathological conditions will find these lines instrumental in elucidating mechanisms of action and understanding disease resilience.
Compared to alternative models, such as overexpression systems or wild-type controls, the knockout approach provides a more authentic representation of gene function, leading to more reliable experimental outcomes. Additionally, these cell lines offer reproducible results with minimal variability, a crucial factor for both academic research and pharmaceutical development.
The value of CDC42BPA Gene Knockout Cell Lines to researchers and clinicians lies in their ability to bridge basic science with translational research, enhancing our understanding of cellular behavior and paving the way for innovative therapeutic strategies. By choosing these specific cell lines, users are backed by a solid foundation of rigorous scientific validation and tailored experimental design.
Our company's expertise in the development of high-quality biological products, combined with cutting-edge genetic engineering techniques, positions us as a leader in providing innovative solutions that empower researchers and clinicians in their quest for understanding complex biological systems.
Please note that all services are for research use only. Not intended for any clinical use.
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