Gene: CD99
Official Full Name: CD99 molecule (Xg blood group)provided by HGNC
Gene Summary: The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. There is a related pseudogene located immediately adjacent to this locus. [provided by RefSeq, Mar 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05705 | CD99 Knockout cell line (HeLa) | Human | CD99 | 1:3~1:6 | Negative | Online Inquiry |
KO05706 | CD99 Knockout cell line (HCT 116) | Human | CD99 | 1:2~1:4 | Negative | Online Inquiry |
KO05707 | CD99 Knockout cell line (HEK293) | Human | CD99 | 1:3~1:6 | Negative | Online Inquiry |
KO05708 | CD99 Knockout cell line (A549) | Human | CD99 | 1:3~1:4 | Negative | Online Inquiry |
CD99 Gene Knockout Cell Lines are expertly engineered cellular models specifically designed to study the function of the CD99 gene, which encodes a cell surface protein involved in various biological processes, including cell adhesion, immune response, and apoptosis. By creating knockout versions of these cell lines, researchers can diminish or eliminate the expression of the CD99 protein, thus facilitating an in-depth analysis of its physiological and pathological roles.
The primary function of these CD99 Gene Knockout Cell Lines lies in their ability to act as robust tools for investigating the impact of CD99 signaling pathways in different cellular contexts. The knockout mechanism typically utilizes CRISPR-Cas9 technology or similar genomic editing techniques to induce precise deletions or frameshift mutations within the CD99 gene. This allows for researchers to evaluate not only the role of CD99 in normal cellular physiology but also its contribution to diseases such as cancer, autoimmunity, and inflammation.
In the realm of scientific importance, these cell lines serve as invaluable resources in both research and clinical applications. They support high-throughput screening for therapeutic agents targeting CD99-related pathways, promote the understanding of immune evasion in tumors, and contribute to advances in personalized medicine by unveiling the role of CD99 in individual patient responses to treatments.
Unique selling points of CD99 Gene Knockout Cell Lines include their high specificity and reliable reproducibility, which are critical for generating consistent experimental results. Compared to traditional methods involving RNA interference, knockout models offer a permanent alteration of gene expression, allowing for long-term studies without the loss of efficacy over time. Additionally, they can provide insights into CD99's interactions with other cellular receptors and pathways, offering a comprehensive view of its biological significance.
For researchers and clinicians alike, investing in CD99 Gene Knockout Cell Lines translates into a strategic advantage in understanding complex biological mechanisms and developing targeted therapies. The ability to study diseases at the molecular level empowers the scientific community to devise innovative approaches to treatment and enhance patient outcomes.
Our company specializes in the development of advanced biological products with a focus on precision and quality. We provide researchers with cutting-edge tools that foster the next generation of breakthrough discoveries in the biosciences.
Please note that all services are for research use only. Not intended for any clinical use.
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