CD70 Knockout Cell Lines

CD70 Gene Knockout Cell Lines are precisely engineered cell lines that have had targeted disruptions of the CD70 gene, a critical component in immune regulation and T-cell activation. The CD70 protein, expressed on activated T cells, plays a vital role in the immune response by interacting with its receptor CD27, leading to the enhancement of T-cell proliferation and survival. By offering these knockout cell lines, researchers can investigate the function of CD70 in a controlled environment, elucidating its role in various immunological pathways, including peripheral tolerance and the modulation of immune responses during infections or tumors.

The knockout mechanism typically employs advanced CRISPR/Cas9 technology or similar gene-editing methodologies, which effectively introduce insertions or deletions in the CD70 gene sequence, leading to a complete loss of protein expression. This allows scientists to study the consequences of CD70 deficiency on cellular behavior, including changes in immune cell activation, cytokine production, and interactions with other immune modulators. Furthermore, these cell lines serve as an invaluable resource for drug development, enabling the screening of novel therapeutics aimed at modulating immune responses for conditions such as cancer, autoimmune diseases, and chronic infections.

A significant advantage of our CD70 Gene Knockout Cell Lines over alternative products is their high specificity and validation through rigorous testing, ensuring reproducibility and reliability in experimental settings. Researchers can trust that our cell lines provide authentic models that reflect the physiological complexity of immune interactions.

By acquiring our CD70 Gene Knockout Cell Lines, researchers and clinicians gain access to a powerful tool that can drive innovations in immunology and therapeutic development. With extensive experience in the production of high-quality biological products, our company stands at the forefront of genetic research tools, consistently delivering excellence to support scientific advancement and impactful discoveries in the field.