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CD63 Knockout Cell Lines

Gene: CD63

Official Full Name: CD63 moleculeprovided by HGNC

Gene Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00332 CD63 Knockout cell line (HeLa) Human CD63 1:3~1:6 Negative Online Inquiry
KO03786 CD63 Knockout cell line (HCT 116) Human CD63 1:2~1:4 Negative Online Inquiry
KO03787 CD63 Knockout cell line (HEK293) Human CD63 1:3~1:6 Negative Online Inquiry
KO03788 CD63 Knockout cell line (A549) Human CD63 1:3~1:4 Negative Online Inquiry

Background

CD63 Gene Knockout Cell Lines represent a pioneering advancement in cellular biology, designed to facilitate research into the cellular functions and roles of the CD63 gene. CD63 is a member of the tetraspanin family and is implicated in various cellular processes, including cell adhesion, signaling, and the immune response. By employing CRISPR-Cas9 technology to create knockout variants, these cell lines allow researchers to investigate the specific roles of CD63 in disease mechanisms, intracellular trafficking, and cellular interactions without the confounding effects of the functional gene.

The knockout mechanism involves the precise insertion of a mutation that disrupts CD63 expression, effectively generating a model for studying aberrant crosstalk and signaling pathways that may contribute to pathological conditions. This precise editing capability not only enhances the accuracy of experimental results but also aids in the identification of novel therapeutic targets for diseases such as cancer, autoimmune disorders, and neurodegenerative diseases.

The scientific importance of CD63 Gene Knockout Cell Lines extends beyond basic research; these models provide essential insights for drug development and the understanding of therapeutic interventions. The ability to observe phenotypic variations in cellular behavior without CD63 allows for the elucidation of its contributions in both health and disease conditions.

Compared to alternative models, such as overexpression systems or conventional knockout models using non-specific methodologies, our CD63 Gene Knockout Cell Lines offer higher specificity and reproducibility. Researchers can rely on these optimized tools to significantly reduce experimental variability and enhance the reliability of their data.

For scientists and clinicians alike, the availability of well-characterized CD63 Gene Knockout Cell Lines represents a valuable resource for advancing research and therapeutic strategies. At [Your Company Name], we are committed to delivering high-quality biological products, supported by a team of experts dedicated to innovation and excellence in cellular biology research.

Please note that all services are for research use only. Not intended for any clinical use.

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