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CD46 Knockout Cell Lines

Gene: CD46

Official Full Name: CD46 moleculeprovided by HGNC

Gene Summary: The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09948 CD46 Knockout cell line (HeLa) Human CD46 1:3~1:6 Negative Online Inquiry
KO09949 CD46 Knockout cell line (HCT 116) Human CD46 1:2~1:4 Negative Online Inquiry
KO09950 CD46 Knockout cell line (HEK293) Human CD46 1:3~1:6 Negative Online Inquiry
KO09951 CD46 Knockout cell line (A549) Human CD46 1:3~1:4 Negative Online Inquiry

Background

CD46 Gene Knockout Cell Lines are genetically engineered cell lines in which the CD46 gene has been systematically disrupted or depleted, resulting in a model that allows researchers to study the functional consequences of CD46 loss in a controlled environment. CD46, also known as membrane cofactor protein, plays a critical role in the immune system by regulating complement activation and protecting host cells from immune-mediated damage. The knockout of this gene impairs its regulatory functions, facilitating investigations into various biological phenomena such as cellular responses, viral infections, and autoimmune diseases.

The primary function of CD46 Gene Knockout Cell Lines is to serve as a platform for experimental studies aimed at elucidating the role of CD46 in cellular interactions, immune evasion, and the pathogenesis of infectious diseases. By disrupting CD46, researchers can observe changes in cell signaling pathways, immune cell activation, and susceptibility to pathogens. Moreover, these cell lines enable the validation of therapeutic targets and the assessment of drug efficacy in modulating immune responses.

In both research and clinical settings, the importance of CD46 Gene Knockout Cell Lines lies in their ability to provide insights into innovative treatment strategies for diseases such as cancer, where immune evasion is a crucial factor. They can also serve as vital tools in vaccine development by aiding the understanding of viral mechanisms that exploit the CD46 pathway.

Compared to alternative models, such as wild-type cell lines or temporary knockdown systems, CD46 Gene Knockout Cell Lines offer a stable and reproducible approach to studying gene function over extended periods. This stability allows for longitudinal studies, providing a more comprehensive view of disease mechanisms and therapeutic responses.

Designed for use by researchers, clinicians, and pharmaceutical developers, the CD46 Gene Knockout Cell Lines represent a significant advancement in experimental biology. They facilitate the exploration of novel hypotheses and the development of targeted therapies, with an emphasis on improving patient outcomes.

Our company is committed to advancing scientific research by providing high-quality genetic tools and reagents, backed by years of expertise in molecular biology and a deep understanding of the complexities of cellular systems. By choosing our CD46 Gene Knockout Cell Lines, you are investing in a product designed to enhance your research capabilities and drive innovation in the field.

Please note that all services are for research use only. Not intended for any clinical use.

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