Gene: CD300H
Official Full Name: CD300H molecule (gene/pseudogene)provided by HGNC
Gene Summary: This gene belongs to the CD300 gene family, which in turn, belongs to the immunoglobulin (Ig) superfamily. This gene is located within a CD300 cluster on chromosome 17. The encoded protein may be involved in innate immunity as well as autoimmune response. A G>A mutation, represented by the single nucleotide polymorphism (SNP) rs905709, at the splice donor site of the 5' terminal exon may be associated with lack of expression of this gene in homozygous (AA) individuals. The human reference assembly (GRCh38.p2) represents the 'A' allele at this SNP. [provided by RefSeq, Apr 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18888 | CD300H Knockout cell line (HeLa) | Human | CD300H | 1:3~1:6 | Negative | Online Inquiry |
KO18889 | CD300H Knockout cell line (HCT 116) | Human | CD300H | 1:2~1:4 | Negative | Online Inquiry |
KO18890 | CD300H Knockout cell line (HEK293) | Human | CD300H | 1:3~1:6 | Negative | Online Inquiry |
KO18891 | CD300H Knockout cell line (A549) | Human | CD300H | 1:3~1:4 | Negative | Online Inquiry |
CD300H Gene Knockout Cell Lines are sophisticated genetic tools that facilitate the study of the CD300H gene, known for its regulatory role in immune response and inflammation. These knockout cell lines have been engineered using CRISPR-Cas9 technology to disrupt the CD300H gene, offering a powerful means to investigate the functional consequences of its absence in various biological contexts.
The primary function of these cell lines is to allow researchers to examine the cellular and molecular mechanisms mediated by CD300H, including its influence on immune cell signaling, activation, and the modulation of cytokine responses. By using these cell lines, scientists can delve into the complex interplay of immune mechanisms, elucidating how CD300H impacts processes like autoimmunity, cancer progression, and infectious disease responses.
The scientific importance of CD300H Gene Knockout Cell Lines is underscored by their wide-ranging applications, which include basic research on immune regulation and drug development processes. They serve as invaluable resources for pharmacological studies aimed at creating therapeutics that modulate immune responses, providing clarity on how inhibiting or activating CD300H could lead to favorable clinical outcomes.
Compared to alternative models, such as traditional knockout mice or transient gene silencing methods, these cell lines offer several advantages: they are easier to manipulate, provide a more controlled environment, and allow for high-throughput screening capabilities. Additionally, they can be maintained in vitro and produce consistent experimental results, which enhances reproducibility and reliability in research findings.
For researchers and clinicians committed to understanding immune mechanisms or developing novel immunotherapies, CD300H Gene Knockout Cell Lines present a critical resource. Our company specializes in providing high-quality biological products backed by rigorous validation and customer support, ensuring that you have the tools necessary to advance your research and clinical applications efficiently.
Please note that all services are for research use only. Not intended for any clinical use.
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