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CD2AP Knockout Cell Lines

Gene: CD2AP

Official Full Name: CD2 associated proteinprovided by HGNC

Gene Summary: This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29073 CD2AP Knockout cell line (HeLa) Human CD2AP 1:3~1:6 Negative Online Inquiry
KO29074 CD2AP Knockout cell line (HCT 116) Human CD2AP 1:2~1:4 Negative Online Inquiry
KO29075 CD2AP Knockout cell line (HEK293) Human CD2AP 1:3~1:6 Negative Online Inquiry
KO29076 CD2AP Knockout cell line (A549) Human CD2AP 1:3~1:4 Negative Online Inquiry

Background

CD2AP Gene Knockout Cell Lines are genetically engineered cell models designed to facilitate the study of the CD2AP gene's role in cellular processes, particularly in immune response and cellular adhesion. These knockout cell lines are engineered to lack the expression of the CD2AP protein, which is crucial for various signaling pathways and cellular functions, including endocytosis and membrane trafficking. By using CRISPR/Cas9 technology or similar genome-editing techniques, researchers can create precise gene disruptions, allowing for comprehensive analysis of the gene's function and its implications in physiological and pathological contexts.

The primary function of these knockout cell lines is to promote advanced research in the areas of immunology, oncology, and neurobiology, where CD2AP plays a significant role. By observing the phenotype and behavior of cells in the absence of CD2AP, researchers can elucidate the mechanistic pathways involved in T cell activation and adhesion to antigen-presenting cells, as well as investigate potential pathways that contribute to neurodegenerative diseases. This makes these cell lines invaluable tools for understanding the underlying mechanisms of various diseases and for the development of targeted therapies.

Compared to traditional models, CD2AP Gene Knockout Cell Lines provide a more precise and relevant platform for studying gene function. Users benefit from the reduced variability often seen in animal models and the ability to perform high-throughput screenings, making these cells ideal for drug development studies. Moreover, these knockout lines allow for the integration of additional genetic modifications or cellular assays, which can produce more tailored and reproducible experimental outcomes.

For researchers and clinicians, the availability of these cell lines represents a critical advancement in the toolkit for exploring gene functionality and interactions. By gaining insights into the role of CD2AP, users can uncover novel therapeutic targets and biomarkers for diseases involving immune dysregulation or cellular misfunction.

Our company specializes in providing state-of-the-art biological products, including genetically engineered cell lines tailored to meet the diverse needs of the scientific community. Leveraging deep expertise in molecular biology and genetic engineering, we are committed to advancing research and therapeutic innovations.

Please note that all services are for research use only. Not intended for any clinical use.

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