Gene: CCR3
Official Full Name: C-C motif chemokine receptor 3provided by HGNC
Gene Summary: The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38506 | CCR3 Knockout cell line (HCT 116) | Human | CCR3 | 1:2~1:4 | Negative | Online Inquiry |
CCR3 Gene Knockout Cell Lines represent a cutting-edge advancement in the field of molecular biology, specifically designed to facilitate the study of chemokine receptors and their role in various physiological and pathological processes. These genetically engineered cell lines have had the CCR3 gene effectively deleted, allowing researchers to investigate cellular responses and signaling pathways without the influence of this particular receptor.
The main function of CCR3 is to act as a receptor for chemokines, which are critical in regulating immune responses and inflammation. By employing the CCR3 Gene Knockout Cell Lines, researchers can dissect the impact of CCR3 absence on cellular functions such as migration, differentiation, and cytokine production. This is particularly valuable in studying diseases exacerbated by aberrant immune responses, including asthma, allergy, and certain cancers.
The scientific importance of CCR3 Gene Knockout Cell Lines cannot be overstated, as they provide a model system that mimics the physiological conditions in humans, offering invaluable insights into therapeutic interventions. Their applications extend into drug discovery, elucidation of disease mechanisms, and the development of targeted therapies aimed at modulating immune cell behavior in clinical settings.
Compared to conventional cell lines, CCR3 Gene Knockout Cell Lines offer significant advantages such as the elimination of background signaling associated with CCR3, which can confound experimental outcomes. Additionally, the precision of gene knockout technology enables reproducibility and consistency in results, ultimately enhancing the reliability of research findings.
For researchers and clinicians alike, the ability to understand CCR3's role in various biological processes is crucial for devising more effective treatments. In the rapidly evolving landscape of immunotherapy and targeted interventions, our CCR3 Gene Knockout Cell Lines stand as a pivotal tool that can accelerate discoveries and improve patient outcomes.
Our company prides itself on its expertise in genetic engineering and bioproduct development, delivering high-quality cell lines that empower researchers to push the boundaries of science and translate findings into real-world applications.
Please note that all services are for research use only. Not intended for any clinical use.
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