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CCNG1 Knockout Cell Lines

Gene: CCNG1

Official Full Name: cyclin G1provided by HGNC

Gene Summary: The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38655 CCNG1 Knockout cell line (HeLa) Human CCNG1 1:3~1:6 Negative Online Inquiry
KO38656 CCNG1 Knockout cell line (HCT 116) Human CCNG1 1:2~1:4 Negative Online Inquiry
KO38657 CCNG1 Knockout cell line (HEK293) Human CCNG1 1:3~1:6 Negative Online Inquiry
KO38658 CCNG1 Knockout cell line (A549) Human CCNG1 1:3~1:4 Negative Online Inquiry

Background

CCNG1 Gene Knockout Cell Lines are engineered biological tools that facilitate the comprehensive study of the cyclin G1 gene (CCNG1) and its associated molecular pathways. By utilizing CRISPR/Cas9 genome editing technology, these knockout cell lines provide researchers with the ability to specifically delete or disrupt the CCNG1 gene, enabling the exploration of its roles in cell cycle regulation, apoptosis, and various disease states, such as cancer.

The key function of these cell lines lies in their ability to mimic gene dysfunctions observed in vivo. By observing the alterations in cellular behavior following the knockout of CCNG1, researchers can gain insights into its regulatory mechanisms, particularly in cellular proliferation and genomic stability. Additionally, these cell lines can serve as vital models for studying the effects of CCNG1 on drug resistance, cellular response to stress, and the molecular underpinnings of oncogenesis.

The scientific importance of CCNG1 Gene Knockout Cell Lines cannot be overstated, as they provide a robust platform for preclinical research and therapeutic development. Investigators can utilize these cell lines in high-throughput screening assays to identify potential compounds that can restore normal function or inhibit the pathways disrupted by CCNG1 deficiency, making them invaluable in both academic and pharmaceutical research settings.

Compared to alternative models, such as wild-type cell lines or non-targeted knockout models, CCNG1 Gene Knockout Cell Lines offer greater specificity and accuracy in investigations related to cyclin G1 functions. They allow for more precise conclusions to be drawn regarding the gene's role in specific biological processes, reducing the potential for off-target effects that can confound results in less sophisticated models.

For researchers and clinicians focused on cell biology, molecular genetics, or cancer research, CCNG1 Gene Knockout Cell Lines represent a powerful asset that accelerates the discovery of novel therapeutic strategies and deepens our understanding of cellular regulation. Our company prides itself on delivering high-quality biological tools backed by rigorous scientific validation and support, ensuring that our customers are equipped with the most effective solutions for their research needs.

Please note that all services are for research use only. Not intended for any clinical use.

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