Gene: CCKBR
Official Full Name: cholecystokinin B receptorprovided by HGNC
Gene Summary: This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08062 | CCKBR Knockout cell line (HEK293) | Human | CCKBR | 1:3~1:6 | Negative | Online Inquiry |
CCKBR Gene Knockout Cell Lines are specialized biological tools that have been meticulously engineered to disrupt the cholecystokinin B receptor (CCKBR) gene, facilitating innovative research in fields such as pharmacology, oncology, and neurobiology. By utilizing state-of-the-art CRISPR/Cas9 technology, these cell lines effectively eliminate CCKBR expression, allowing researchers to investigate the receptor’s role in various physiological processes and its implications in disease mechanisms.
The key function of these knockout cell lines lies in their ability to create a controlled environment where the effects of CCKBR loss can be meticulously studied. This is achieved through precise genomic editing, which reduces variability in experimental results and enhances reproducibility. Researchers can explore cellular signaling pathways influenced by CCKBR, thus paving the way for advancements in drug discovery and therapeutic interventions targeting receptor-related pathways.
The scientific importance of CCKBR Gene Knockout Cell Lines is profound, especially in studying gastrointestinal disorders, anxiety, and certain cancers where CCKBR plays a crucial role. Moreover, their application extends to drug development processes, providing invaluable insights into how potential compounds affect CCKBR-expressing cells versus knockout variants. These insights can lead to more targeted and effective therapeutic strategies.
What sets CCKBR Gene Knockout Cell Lines apart from alternative models is their specificity, ease of use, and the comprehensiveness of phenotype characterization offered. Unlike transient knockdowns, these stable knockout lines provide long-term studies with consistent expression profiles, making them ideal for complex experimental designs.
For researchers and clinicians, the value of these cell lines cannot be overstated; they offer a powerful platform to unlock new avenues in understanding drug responses and receptor interactions, ultimately contributing to more effective therapies. Our company, with its robust expertise in gene editing and cellular biology, is dedicated to providing high-quality biological products that meet the diverse research needs of today’s scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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