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CCDC125 Knockout Cell Lines

Gene: CCDC125

Official Full Name: coiled-coil domain containing 125provided by HGNC

Gene Summary: Enables identical protein binding activity. Involved in activation of GTPase activity; negative regulation of Rho protein signal transduction; and negative regulation of cell motility. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36780 CCDC125 Knockout cell line (HeLa) Human CCDC125 1:3~1:6 Negative Online Inquiry
KO36781 CCDC125 Knockout cell line (HCT 116) Human CCDC125 1:2~1:4 Negative Online Inquiry
KO36782 CCDC125 Knockout cell line (HEK293) Human CCDC125 1:3~1:6 Negative Online Inquiry
KO36783 CCDC125 Knockout cell line (A549) Human CCDC125 1:3~1:4 Negative Online Inquiry

Background

CCDC125 Gene Knockout Cell Lines are a specially engineered set of mammalian cell lines designed to provide researchers with powerful tools for the study of gene function, protein interactions, and cellular processes. By employing CRISPR-Cas9 technology, these cell lines have been precisely modified to disrupt the CCDC125 gene, a gene implicated in various biological processes and disease states, particularly those related to ciliary function and cellular signaling mechanisms.

The key function of the CCDC125 knockout cell lines lies in their ability to mimic pathological states associated with disrupted CCDC125 expression. This enables a multi-faceted analysis of cellular behavior, including investigations into ciliary assembly, intracellular transport, and signal transduction pathways. Such insights are crucial for understanding the role of ciliary defects in diseases such as ciliopathies, cancer, and cardiovascular disorders.

From a scientific perspective, the applications of these cell lines extend to basic research, drug development, and therapeutic studies. They facilitate high-throughput screening for potential drug candidates that target pathways influenced by CCDC125, making them invaluable in preclinical research. Furthermore, the specificity of the knockout allows for clearer interpretations of experimental results, thereby reducing background noise that can confound data analysis.

Compared to alternative methods of gene manipulation, CCDC125 Gene Knockout Cell Lines present unique advantages, including stable and reproducible gene disruption, ease of handling, and compatibility with various assays such as Western blotting and flow cytometry. Their robustness ensures that researchers can achieve consistent results across experimental replicates, enhancing the credibility of their findings.

These cell lines are particularly valuable for researchers and clinicians who are keen on elucidating the mechanistic roles of specific genes in disease and for those targeting innovative therapeutic strategies. Researchers can accelerate their projects with the confidence that these cell lines will provide reliable, reproducible data essential for advancing scientific knowledge and clinical applications.

Our company specializes in providing high-quality genetic tools, including a wide range of knockout and transgenic cell lines. Our commitment to excellence and innovation in the field of genetic engineering ensures that researchers have access to cutting-edge resources that drive discovery and enhance the understanding of complex biological systems.

Please note that all services are for research use only. Not intended for any clinical use.

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