Home / CBX5 Knockout Cell Lines

CBX5 Knockout Cell Lines

Gene: CBX5

Official Full Name: chromobox 5provided by HGNC

Gene Summary: This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03762 CBX5 Knockout cell line (HeLa) Human CBX5 1:3~1:6 Negative Online Inquiry
KO03763 CBX5 Knockout cell line (HCT 116) Human CBX5 1:2~1:4 Negative Online Inquiry
KO03764 CBX5 Knockout cell line (HEK293) Human CBX5 1:3~1:6 Negative Online Inquiry
KO03765 CBX5 Knockout cell line (A549) Human CBX5 1:3~1:4 Negative Online Inquiry

Background

CBX5 Gene Knockout Cell Lines represent a novel biological tool specifically engineered to facilitate the study of chromatin biology and gene regulation mechanisms. These cell lines have been meticulously crafted using the CRISPR-Cas9 gene-editing technology to create knockout models of the CBX5 gene, which encodes for chromobox protein 5. This protein plays a crucial role in regulating gene expression through its involvement in chromatin remodeling and the formation of transcriptional repression complexes.

The primary function of these knockout cell lines is to enable researchers to understand the effects of the absence of CBX5 on cellular processes, gene expression profiles, and the consequent implications for disease pathways. By examining these cell lines, scientists can elucidate the role of CBX5 in various biological contexts, including cellular proliferation, differentiation, and response to DNA damage, ultimately advancing our understanding of cancer biology and epigenetics.

In the research and clinical landscapes, the scientific importance of CBX5 Gene Knockout Cell Lines cannot be overstated. They serve as invaluable models for drug discovery, therapeutic target validation, and the development of novel epigenetic therapies. Researchers can leverage these models to investigate the therapeutic potential of CBX5 modulation in diseases characterized by aberrant gene expression regulation, such as certain cancers, making them a pivotal asset in translational research.

What sets CBX5 Gene Knockout Cell Lines apart from alternative models is their precision and reliability. Unlike transient knockdown approaches that can yield inconsistent results, these knockout lines provide a stable platform that reflects the loss of CBX5 expression, ensuring reproducibility in studies. Furthermore, our rigorous validation processes confirm the specificity and efficiency of the gene editing, offering users unparalleled confidence in their experimental outcomes.

For researchers and clinicians aiming to deepen their understanding of gene function and develop cutting-edge therapeutic strategies, CBX5 Gene Knockout Cell Lines are a critical addition to their toolkit. Our company is dedicated to advancing scientific research with products designed to enhance experimental efficacy and reliability, backed by our years of expertise in genetic engineering and cell line development.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.