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CBX2 Knockout Cell Lines

Gene: CBX2

Official Full Name: chromobox 2provided by HGNC

Gene Summary: This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24668 CBX2 Knockout cell line (HeLa) Human CBX2 1:3~1:6 Negative Online Inquiry
KO24669 CBX2 Knockout cell line (HCT 116) Human CBX2 1:2~1:4 Negative Online Inquiry
KO24670 CBX2 Knockout cell line (HEK293) Human CBX2 1:3~1:6 Negative Online Inquiry
KO24671 CBX2 Knockout cell line (A549) Human CBX2 1:3~1:4 Negative Online Inquiry

Background

CBX2 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to have a knockout of the CBX2 gene, which plays a crucial role in chromatin organization and gene expression regulation. By utilizing CRISPR/Cas9 gene-editing technology, these cell lines facilitate the investigation of CBX2's functions in cellular processes, including development, cancer progression, and epigenetic regulation. The precise disruption of the CBX2 gene allows researchers to observe changes in gene expression profiles, cellular phenotype, and interactions with other epigenetic factors, thereby elucidating the gene's role in various biological contexts.

The functioning of the CBX2 Gene Knockout Cell Lines hinges on the disruption of the Polycomb group proteins, which are responsible for maintaining the silenced state of specific genes. By knocking out CBX2, essential pathways and regulatory mechanisms can be studied to understand the consequences of CBX2 loss in cellular dynamics, migration, and differentiation, contributing valuable insights into disease models.

From a scientific perspective, these cell lines are invaluable tools not only in basic research but also in preclinical studies, allowing for exploration into the therapeutic targeting of CBX2 in cancers and other diseases involving epigenetic dysregulation. Their applications extend to drug development, where understanding how gene silencing operates can lead to novel interventions.

Distinct from other alternatives, CBX2 Gene Knockout Cell Lines offer specificity and reliability, validated through extensive characterization. Researchers will appreciate that these cell lines are created using state-of-the-art methodologies, ensuring high efficiency and minimal off-target effects. Furthermore, they are provided with comprehensive user protocols and support, making them readily accessible for varying expertise levels in research settings.

By choosing our CBX2 Gene Knockout Cell Lines, researchers and clinicians can leverage a product grounded in scientific rigor and innovation, contributing significantly to the advancement of genetics and therapeutic development. Our company's commitment to quality and excellence in biological products allows users to experience confidence and reliability in their research pursuits.

Please note that all services are for research use only. Not intended for any clinical use.

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