Gene: CBX1
Official Full Name: chromobox 1provided by HGNC
Gene Summary: This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05107 | CBX1 Knockout cell line (HeLa) | Human | CBX1 | 1:3~1:6 | Negative | Online Inquiry |
KO05108 | CBX1 Knockout cell line (HCT 116) | Human | CBX1 | 1:2~1:4 | Negative | Online Inquiry |
KO05109 | CBX1 Knockout cell line (HEK293) | Human | CBX1 | 1:3~1:6 | Negative | Online Inquiry |
KO05110 | CBX1 Knockout cell line (A549) | Human | CBX1 | 1:3~1:4 | Negative | Online Inquiry |
CBX1 Gene Knockout Cell Lines are genetically engineered cell models designed to specifically deactivate the chromobox 1 (CBX1) gene, which plays a crucial role in various biological processes, including gene regulation and chromatin organization. These cell lines facilitate the study of CBX1 function by providing a controlled environment to examine cellular behaviors and molecular mechanisms that emerge in its absence.
The primary function of CBX1 is to ensure proper gene silencing and maintenance of heterochromatin structure. By disrupting CBX1 expression, the knockout cell lines enable researchers to observe alterations in chromatin dynamics, gene expression profiles, and cellular pathways. This offers insights into its involvement in critical processes such as cell proliferation, differentiation, and response to external stimuli. The mechanisms by which CBX1 exerts its influence can thus be dissected more fully in cellular systems lacking this essential gene.
In research and clinical settings, CBX1 Gene Knockout Cell Lines hold significant scientific importance, especially in cancer biology and developmental studies. Abnormalities in chromatin regulation, commonly associated with cancer progression, can be modeled using these cell lines, providing valuable data that could lead to novel therapeutic targets. Furthermore, these cell lines serve as a platform to test drugs that may restore normal function or counteract the effects of CBX1 deficiency.
Compared to alternative models, such as transient knockdown methods, CBX1 Gene Knockout Cell Lines offer stable and consistent gene disruption. This stability is vital for long-term experiments, ensuring reproducibility and reliability of results. Additionally, these cell lines can be tailored for specific applications, such as functional genomics or high-throughput screening, enhancing their versatility.
For researchers and clinicians focused on elucidating the roles of chromatin proteins in health and disease, CBX1 Gene Knockout Cell Lines present unparalleled value. Their ability to mirror real-life biological contexts makes them indispensable tools in advancing our understanding of cellular mechanisms and potential disease treatments. Our company specializes in high-quality genetic tools that empower researchers to push the boundaries of biological knowledge, and we are committed to providing state-of-the-art products that support transformative research.
Please note that all services are for research use only. Not intended for any clinical use.
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