Gene: CBFA2T2
Official Full Name: CBFA2/RUNX1 partner transcriptional co-repressor 2provided by HGNC
Gene Summary: In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33549 | CBFA2T2 Knockout cell line (HeLa) | Human | CBFA2T2 | 1:3~1:6 | Negative | Online Inquiry |
KO33550 | CBFA2T2 Knockout cell line (HCT 116) | Human | CBFA2T2 | 1:2~1:4 | Negative | Online Inquiry |
KO33551 | CBFA2T2 Knockout cell line (HEK293) | Human | CBFA2T2 | 1:3~1:6 | Negative | Online Inquiry |
KO33552 | CBFA2T2 Knockout cell line (A549) | Human | CBFA2T2 | 1:3~1:4 | Negative | Online Inquiry |
CBFA2T2 Gene Knockout Cell Lines are specially developed cellular models in which the CBFA2T2 gene has been selectively disrupted, allowing researchers to investigate the biological role of this gene in various physiological and pathological contexts. This gene, part of the core binding factor family, has been implicated in critical processes such as hematopoiesis, cell differentiation, and the regulation of transcription during development. By utilizing these knockout cell lines, scientists can isolate the functional contributions of the CBFA2T2 gene and elucidate its pathways in disease models.
The primary function of these cell lines lies in their ability to facilitate the study of gene function through loss-of-function analysis. By understanding the consequences of the absence of CBFA2T2, researchers can gain insights into its role in cellular signaling, gene expression, and potential oncogenic activities. These insights are invaluable in clinical research, particularly in understanding hematological malignancies where dysregulation of transcription factors often plays a pivotal role.
The scientific importance of CBFA2T2 Gene Knockout Cell Lines extends to their application in drug discovery and development. Researchers can employ these models to screen for therapeutic compounds that may restore normal function or inhibit aberrant pathways activated by CBFA2T2 dysregulation. Furthermore, they serve as vital tools in genetic research, allowing for the exploration of gene interactions and the mapping of genetic networks.
One of the key advantages of our CBFA2T2 Gene Knockout Cell Lines is their rigorous validation and characterization, ensuring reproducibility and reliability in experimental results. Compared to alternative models, such as transient knockdown systems, these stable cell lines provide a more robust platform for long-term studies, thus increasing the reliability of data generated over extended periods.
For researchers and clinicians, the availability of these knockout cell lines significantly enhances experimental design, supporting the quest for novel therapeutic strategies and the advancement of knowledge in molecular biology. By choosing our CBFA2T2 Gene Knockout Cell Lines, users align with a product backed by extensive scientific expertise and commitment to quality. Our company is dedicated to providing biologically accurate models that drive innovation and facilitate breakthroughs in research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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