Gene: CAVIN1
Official Full Name: caveolae associated protein 1provided by HGNC
Gene Summary: This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05065 | CAVIN1 Knockout cell line (HeLa) | Human | CAVIN1 | 1:3~1:6 | Negative | Online Inquiry |
KO05066 | CAVIN1 Knockout cell line (HCT 116) | Human | CAVIN1 | 1:2~1:4 | Negative | Online Inquiry |
KO05067 | CAVIN1 Knockout cell line (HEK293) | Human | CAVIN1 | 1:3~1:6 | Negative | Online Inquiry |
KO05068 | CAVIN1 Knockout cell line (A549) | Human | CAVIN1 | 1:3~1:4 | Negative | Online Inquiry |
CAVIN1 Gene Knockout Cell Lines represent a sophisticated tool designed for the exploration of cellular mechanisms and processes mediated by CAVIN1, a crucial player in caveolae formation, lipid metabolism, and cellular signaling. These cell lines are genetically engineered to lack CAVIN1 expression, enabling researchers to elucidate the role of this protein in various biological contexts. By employing CRISPR/Cas9 technology, the complete knockout of the gene allows for detailed studies of its impacts on cellular function and architecture.
One of the key functions of CAVIN1 involves its participation in lipid raft formation and the regulation of endocytosis, given its integral role in the organization of caveolae—small invaginations of the plasma membrane. Disruption of CAVIN1 can lead to significant alterations in cellular signaling pathways and metabolic processes, making these knockout cell lines vital for investigating conditions such as obesity, diabetes, and cardiovascular disease.
The scientific importance of CAVIN1 Gene Knockout Cell Lines extends to both research and clinical applications. In a research setting, they provide insights into the molecular underpinnings of diseases associated with lipid dysregulation and membrane trafficking. Clinically, understanding these pathways can facilitate the development of targeted therapies, potentially improving patient outcomes in metabolic disorders.
What sets our CAVIN1 Gene Knockout Cell Lines apart from alternatives on the market is the precision and reliability achieved through our proprietary knockout methodology, which ensures a complete absence of CAVIN1 expression without off-target effects. This specificity not only enhances experimental reproducibility but also minimizes confounding variables, enabling researchers to trust their findings.
Researchers and clinicians should consider investing in CAVIN1 Gene Knockout Cell Lines for reliable insights into cellular mechanisms impacting a wide range of biological phenomena. Our commitment to excellence in genetic engineering and cell line development underscores our expertise, providing high-quality products that contribute to advancing scientific knowledge and therapeutic innovations. Together, we aim to empower scientists in their quest to unravel the complexities of biology.
Please note that all services are for research use only. Not intended for any clinical use.
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