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CASP3 Knockout Cell Lines

Gene: CASP3

Official Full Name: caspase 3provided by HGNC

Gene Summary: The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10895 CASP3 Knockout cell line (HeLa) Human CASP3 1:3~1:6 Negative Online Inquiry
KO10896 CASP3 Knockout cell line (HCT 116) Human CASP3 1:2~1:4 Negative Online Inquiry
KO10897 CASP3 Knockout cell line (HEK293) Human CASP3 1:3~1:6 Negative Online Inquiry
KO10898 CASP3 Knockout cell line (A549) Human CASP3 1:3~1:4 Negative Online Inquiry

Background

CASP3 Gene Knockout Cell Lines represent a pivotal advancement in the field of molecular biology and genetic research. These specialized cell lines have been genetically engineered to lack the caspase-3 (CASP3) gene, which encodes a crucial effector enzyme in the apoptotic pathway. By eliminating this gene, researchers can gain invaluable insights into the mechanisms of apoptosis, as CASP3 is known to play a significant role in programmed cell death, influencing cellular responses to various stimuli, including stress and therapeutic agents.

The principal function of CASP3 Gene Knockout Cell Lines is to facilitate the study of apoptosis and related signaling pathways without the confounding influence of caspase-3 activity. This allows for a clearer understanding of alternative cell death mechanisms, the role of apoptosis in cancer progression, and the evaluation of drug responses in a controlled environment. Researchers can utilize these cell lines to examine the compensatory pathways activated in the absence of CASP3, thus shedding light on the complexities of cellular survival strategies.

In both research and clinical settings, CASP3 Gene Knockout Cell Lines hold significant scientific importance. They serve as valuable tools in cancer research, drug development, and the investigation of neurodegenerative diseases, as understanding apoptosis can guide therapeutic interventions. Their capability to support high-throughput screening and target validation enhances their utility in translational research endeavors.

One of the standout advantages of CASP3 Gene Knockout Cell Lines is the specificity of the knockout technique, which allows for precise examination of the absence of caspase-3 without off-target effects, a common issue in many alternative methods. This high level of specificity improves the reliability of experimental results, thereby making conclusions more robust.

Essentially, the value of CASP3 Gene Knockout Cell Lines to researchers, clinicians, and pharmaceutical companies lies in their ability to elucidate the intricate processes of apoptosis. By using these cell lines, users can accelerate their research while potentially leading to innovative breakthroughs in treatment strategies.

Our company prides itself on its expertise in the development of innovative biological products, ensuring that researchers have access to state-of-the-art tools like the CASP3 Gene Knockout Cell Lines to drive their scientific discoveries forward.

Please note that all services are for research use only. Not intended for any clinical use.

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