Gene: CAPN12
Official Full Name: calpain 12provided by HGNC
Gene Summary: The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. [provided by RefSeq, Jun 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO23551 | CAPN12 Knockout cell line (HCT 116) | Human | CAPN12 | 1:2~1:4 | Negative | Online Inquiry |
KO23552 | CAPN12 Knockout cell line (A549) | Human | CAPN12 | 1:3~1:4 | Negative | Online Inquiry |
CAPN12 Gene Knockout Cell Lines are a powerful tool designed to facilitate the exploration of calpain-12 (CAPN12) function in various biological processes. Calpains are a family of calcium-dependent cysteine proteases involved in multiple cellular mechanisms, including apoptosis, cell cycle regulation, and signal transduction. By providing researchers with engineered cell lines that have the CAPN12 gene knocked out, these products allow for a more focused study on the role of CAPN12 in health and disease.
The key function of these knockout cell lines lies in their ability to elucidate the impact of CAPN12 deficiency on cellular behavior. The absence of CAPN12 allows scientists to investigate downstream signaling pathways and related metabolic processes that may be altered due to its absence. This functional analysis can yield insights into diseases where calpain activity is implicated, such as cancer, neurodegenerative disorders, and heart disease, thus providing a critical understanding of CAPN12's biological significance.
In scientific research and clinical settings, CAPN12 Gene Knockout Cell Lines are invaluable. They enable researchers to create models that mimic human disease conditions, facilitating drug discovery and therapeutic development. Moreover, they serve as a platform for investigating gene function and regulation, which is fundamental in the field of molecular biology.
One of the standout advantages of our CAPN12 Gene Knockout Cell Lines is their precision; each line is constructed using state-of-the-art CRISPR/Cas9 technology, ensuring specific and efficient gene disruption. Unlike alternative methods, which may yield off-target effects or incomplete knockouts, our cell lines offer a more reliable and reproducible model for experimentation.
These cell lines are a vital asset for researchers, providing them with a definitive tool to delineate the role of CAPN12 in various physiological and pathological contexts. Their versatility makes them suitable for a range of studies, from basic research to targeted therapeutic investigations.
Leveraging years of expertise in genetic engineering and cellular biology, our company is dedicated to providing high-quality biological products and innovative solutions that support research advancements in the life sciences. Our commitment to excellence ensures that researchers have access to the best tools to propel their discoveries forward.
Please note that all services are for research use only. Not intended for any clinical use.
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