Gene: CALB1
Official Full Name: calbindin 1provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38711 | CALB1 Knockout cell line (HEK293) | Human | CALB1 | 1:3~1:6 | Negative | Online Inquiry |
CALB1 Gene Knockout Cell Lines are genetically engineered cell lines that have been specifically modified to disrupt the expression of the CALB1 gene, which encodes for the calcium-binding protein calbindin. These cell lines serve as invaluable tools for researchers aiming to elucidate the functional roles of CALB1 in various biological processes, including calcium homeostasis, neuronal signaling, and muscle function. By inhibiting the expression of this critical gene, users can investigate the downstream effects and regulatory pathways influenced by CALB1, providing insights into its role in health and disease.
The key mechanism of action for CALB1 Gene Knockout Cell Lines lies in the targeted disruption of gene expression through techniques such as CRISPR-Cas9 or homologous recombination. This results in the loss of CALB1 protein, allowing for the analysis of phenotypic changes and cellular responses that are dependent on calcium signaling. Researchers can utilize these cell lines to study various physiological and pathological conditions, including neurodegenerative diseases, cardiac dysfunction, and developmental disorders, thereby contributing to a deeper understanding of the underlying molecular mechanisms.
In clinical and research settings, CALB1 Gene Knockout Cell Lines are crucial for drug discovery, biomarker identification, and the development of novel therapeutic strategies. Their ability to model specific genetic alterations makes them particularly valuable for examining the effects of gene modifications and perturbations in cellular behavior.
What sets CALB1 Gene Knockout Cell Lines apart from traditional cell lines is their precision and targeted approach to gene disruption. Unlike non-specific gene silencing techniques, these knockout lines offer a clear genetic background, enabling reproducible results and robust data interpretation. This specificity translates to more effective and interpretable research outcomes, giving scientists a significant edge in their studies.
For researchers and clinicians focused on calcium biology and its implications in disease, CALB1 Gene Knockout Cell Lines represent a significant advancement in the toolkit available to them. Leveraging our expertise in genetic engineering and cellular manipulation, we ensure that our products meet the highest standards of quality, allowing our users to confidently advance their research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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