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CADPS2 Knockout Cell Lines

Gene: CADPS2

Official Full Name: calcium dependent secretion activator 2provided by HGNC

Gene Summary: This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22132 CADPS2 Knockout cell line (HCT 116) Human CADPS2 1:2~1:4 Negative Online Inquiry
KO22133 CADPS2 Knockout cell line (HEK293) Human CADPS2 1:3~1:6 Negative Online Inquiry

Background

CADPS2 Gene Knockout Cell Lines are genetically engineered cellular models designed to study the functions and pathophysiological roles of the CADPS2 gene, which encodes a calcium-dependent activator protein involved in neurotransmitter release. These cell lines are created using advanced CRISPR-Cas9 gene-editing technologies, enabling precise deletion of the CADPS2 gene to elucidate its cellular functions and contributions to neurological processes. By observing the effects of CADPS2 knockout, researchers can gain insight into synaptic mechanisms, plasticity, and related neurophysiological conditions.

The mechanisms through which CADPS2 affects neuronal behavior are primarily linked to its role in facilitating the docking and fusion of synaptic vesicles at the presynaptic membrane. This knockdown model presents a powerful tool for researchers investigating calcium-dependent neurotransmitter release and its implications in disorders such as autism spectrum disorder, schizophrenia, and bipolar disorder. The biological relevance of CADPS2 in these contexts underscores its potential utility in both basic and translational research.

CADPS2 Gene Knockout Cell Lines are uniquely positioned in the market due to their high specificity and reproducibility compared to traditional models. These knockout cell lines provide a steady platform for high-throughput screening and drug discovery, allowing researchers to evaluate the efficacy and specificity of therapeutic compounds targeting the synaptic pathway influenced by CADPS2. Moreover, the availability of well-characterized, genetically modified cell lines decreases variability, enhancing experimental precision and reliability.

For researchers and clinicians focused on neurobiology and neuropharmacology, CADPS2 Gene Knockout Cell Lines represent an invaluable resource, streamlining studies aimed at unraveling the complexities of gene function and neuropharmaceutical development. Our company, renowned for its commitment to cutting-edge genetic engineering solutions, provides these specialized cell lines alongside expert technical support and comprehensive documentation, ensuring that clients can effectively harness the full potential of their research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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