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CACNA1B Knockout Cell Lines

Gene: CACNA1B

Official Full Name: calcium voltage-gated channel subunit alpha1 Bprovided by HGNC

Gene Summary: The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10922 CACNA1B Knockout cell line (HCT 116) Human CACNA1B 1:2~1:4 Negative Online Inquiry

Background

CACNA1B Gene Knockout Cell Lines represent a cutting-edge biotechnological tool designed to facilitate the study of voltage-gated calcium channels, specifically the CACNA1B gene, which encodes the α1B subunit of the N-type calcium channel. These cell lines are genetically engineered to eliminate the expression of the CACNA1B gene, enabling researchers to explore the physiological and pathological roles of this critical ion channel in cell signaling pathways and neurotransmitter release.

The primary function of these knockout cell lines is to provide a controlled environment for investigating the physiological effects of calcium influx and its implications in various cellular processes, such as synaptic transmission and muscle contraction. By utilizing these cell lines, researchers can employ techniques such as electrophysiology, imaging, and biochemical assays to elucidate the cellular mechanisms influenced by calcium signaling. Moreover, these cell lines serve as a powerful platform for drug screening and development, allowing for the identification of compounds that modulate channel activity or offer therapeutic targets for neurological disorders and pain management.

The scientific importance of the CACNA1B Gene Knockout Cell Lines lies in their application across multiple research domains. They provide invaluable insights into neurobiology, cardiovascular physiology, and potential treatments for conditions such as epilepsy, migraines, and chronic pain syndromes. Compared to traditional models, such as whole-animal studies or primary cell cultures, these knockout cell lines offer reduced variability and increased reproducibility in experimental results.

One of the unique selling points of our CACNA1B Gene Knockout Cell Lines is the assurance of high-quality, validated genetic modifications, which facilitate ease of use for researchers in diverse fields. Additionally, our cell lines are optimized for proliferation, ensuring a reliable supply, which significantly reduces research time and resource commitment.

In an era where precision medicine and targeted therapies are on the rise, CACNA1B Gene Knockout Cell Lines empower researchers and clinicians to make advancements in understanding complex biological systems. Our company prides itself on its expertise in genetic engineering and commitment to providing high-quality biological tools that enhance research capabilities and foster scientific innovation. The CACNA1B Gene Knockout Cell Lines are, therefore, not just products but essential resources for the future of biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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