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CABYR Knockout Cell Lines

Gene: CABYR

Official Full Name: calcium binding tyrosine phosphorylation regulatedprovided by HGNC

Gene Summary: To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28185 CABYR Knockout cell line (HeLa) Human CABYR 1:3~1:6 Negative Online Inquiry
KO28186 CABYR Knockout cell line (HEK293) Human CABYR 1:3~1:6 Negative Online Inquiry
KO28187 CABYR Knockout cell line (A549) Human CABYR 1:3~1:4 Negative Online Inquiry

Background

CABYR Gene Knockout Cell Lines are a specialized collection of cell lines engineered to lack the expression of the CABYR gene, which encodes for a critical protein involved in male fertility and reproductive processes. By employing advanced gene-editing techniques such as CRISPR/Cas9, these cell lines provide an invaluable tool for researchers seeking to elucidate the functional roles of CABYR in various biological contexts, particularly those related to spermatogenesis and sperm function.

The primary mechanism by which CABYR Gene Knockout Cell Lines operate involves the precise alteration of the genomic sequence to create a loss-of-function model. This presents an opportunity to investigate the downstream effects of CABYR deficiency on cellular pathways, especially those linked to molecular signaling and cellular dynamics during gametogenesis. Researchers can use these knockout lines to study phenotypic changes, perform gene expression analyses, and explore the potential compensatory mechanisms activated in the absence of CABYR, thereby enhancing our understanding of male reproductive biology.

The scientific significance of CABYR Gene Knockout Cell Lines extends to both fundamental research and clinical applications. In a research setting, they can facilitate investigations into male infertility, providing insights into new therapeutic targets and potential interventions. Clinically, these cell lines can aid in the development of fertility treatments or diagnostic tools, thereby having a direct impact on reproductive health outcomes.

What sets CABYR Gene Knockout Cell Lines apart from alternative models is their specificity and reliability. Unlike traditional models that may exhibit compensatory effects or are less precise in gene targeting, these engineered lines are designed for optimal performance in various experimental conditions. Their robustness allows for consistent replication of results, making them an ideal choice for laboratories focused on reproductive biology and associated fields.

Researchers and clinicians will find significant value in CABYR Gene Knockout Cell Lines, as they not only contribute to advancing the understanding of complex reproductive mechanisms but also pave the way for innovative therapeutic solutions in infertility treatment. Our company specializes in high-quality gene-editing tools and cell line development, ensuring that researchers are equipped with the best resources to drive their investigations forward.

Please note that all services are for research use only. Not intended for any clinical use.

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