Gene: CABLES1
Official Full Name: Cdk5 and Abl enzyme substrate 1provided by HGNC
Gene Summary: This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04323 | CABLES1 Knockout cell line (HeLa) | Human | CABLES1 | 1:3~1:6 | Negative | Online Inquiry |
KO04324 | CABLES1 Knockout cell line (HCT 116) | Human | CABLES1 | 1:2~1:4 | Negative | Online Inquiry |
KO04325 | CABLES1 Knockout cell line (HEK293) | Human | CABLES1 | 1:3~1:6 | Negative | Online Inquiry |
KO04326 | CABLES1 Knockout cell line (A549) | Human | CABLES1 | 1:3~1:4 | Negative | Online Inquiry |
CABLES1 Gene Knockout Cell Lines are genetically engineered cellular models in which the CABLES1 gene has been specifically knocked out using advanced CRISPR/Cas9 technology. This essential product allows researchers to investigate the biological role of the CABLES1 gene, which is implicated in various cellular processes, including cell cycle regulation, apoptosis, and tumorigenesis. By creating these knockout models, scientists can study the consequences of CABLES1 deficiency and explore its impacts on cellular behavior, signaling pathways, and disease mechanisms.
The CABLES1 knockout cell lines function by providing a controlled environment where the absence of the CABLES1 protein allows for a clearer understanding of its cellular interactions and functional roles. This specificity enables researchers to observe alterations in cell growth, differentiation, and response to pharmacological agents, thereby illuminating potential therapeutic targets for cancer therapies and other diseases influenced by this gene's regulation.
Scientifically, these cell lines hold immense importance in both fundamental and translational research. They serve as critical tools in drug development and validate theories regarding the CABLES1 gene's contribution to oncogenesis. Their usage spans academic laboratories focused on cellular biology, as well as pharmaceutical enterprises looking to derive targeted interventions in cancer treatment.
What sets CABLES1 Gene Knockout Cell Lines apart from alternative models is their precision and consistency. Unlike traditional methods that may involve partial knockdowns or varied genetic backgrounds, our knockout lines ensure complete absence of the target protein—allowing for more reliable and reproducible research outcomes. These lines are also readily adaptable for high-throughput screening, thereby enhancing their versatility in experimental designs.
For researchers and clinicians looking to delve deeper into the molecular nuances of cancer biology or gene function, these cell lines offer invaluable insights. Their ability to facilitate clearer interpretations of experimental data significantly accelerates the pace of discovery, leading to better therapeutic strategies.
Our company prides itself on expertise in genetic engineering and cellular biology, providing a range of high-quality, validated cell lines that empower scientists in their quest to advance biomedical research. With a commitment to innovation and scientific integrity, we aim to support your research endeavors with world-class biological products tailored to meet the highest standards.
Please note that all services are for research use only. Not intended for any clinical use.
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