Gene: CA9
Official Full Name: carbonic anhydrase 9provided by HGNC
Gene Summary: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jun 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09981 | CA9 Knockout cell line (HeLa) | Human | CA9 | 1:3~1:6 | Negative | Online Inquiry |
KO09982 | CA9 Knockout cell line (A549) | Human | CA9 | 1:3~1:4 | Negative | Online Inquiry |
CA9 Gene Knockout Cell Lines represent a pivotal advancement in genetic research, specifically designed for the functional study of the carbonic anhydrase IX (CA9) gene. This gene is critical in regulating intra- and extracellular pH levels and playing significant roles in tumor physiology and metabolic pathways. The creation of these knockout cell lines allows researchers to investigate the biological functions and regulatory mechanisms elicited by CA9, linking its expression to various pathological conditions, especially in cancer.
These cell lines are engineered through targeted CRISPR/Cas9 gene editing technologies, which enable precise disruption of the CA9 gene, leading to the loss of function. By studying CA9-deficient models, researchers can elucidate its role in tumor growth, hypoxic adaptation, and cellular metabolic changes that occur in cancerous tissues. Such insights are invaluable in the fields of oncology and metabolic research, where alternative therapeutic strategies are actively being sought.
From a scientific perspective, the CA9 Gene Knockout Cell Lines offer unique advantages over conventional methods for examining gene function. They provide a versatile and reproducible model system that can be used to validate potential therapeutic targets and assess the efficacy of novel treatment approaches in preclinical studies. By utilizing these sophisticated cell lines, laboratories can accelerate their research timelines and enhance the reliability of their findings.
For clinicians and researchers dedicated to understanding the complexities of cancer biology and the therapeutic implications of targeting CA9, these knockout cell lines serve as a crucial tool. Their availability empowers scientific inquiry, fosters collaboration, and drives innovation across various research initiatives.
Our company prides itself on delivering high-quality biological products backed by extensive expertise in molecular biology and genetics. We remain committed to supporting the scientific community with innovative solutions, like the CA9 Gene Knockout Cell Lines, that enhance research capabilities and contribute to the advancement of therapeutic modalities.
Please note that all services are for research use only. Not intended for any clinical use.
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