Gene: CA2
Official Full Name: carbonic anhydrase 2provided by HGNC
Gene Summary: The protein encoded by this gene is one of several isozymes of carbonic anhydrase, which catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38734 | CA2 Knockout cell line (HeLa) | Human | CA2 | 1:3~1:6 | Negative | Online Inquiry |
KO38735 | CA2 Knockout cell line (HCT 116) | Human | CA2 | 1:2~1:4 | Negative | Online Inquiry |
KO38736 | CA2 Knockout cell line (HEK293) | Human | CA2 | 1:3~1:6 | Negative | Online Inquiry |
KO38737 | CA2 Knockout cell line (A549) | Human | CA2 | 1:3~1:4 | Negative | Online Inquiry |
CA2 Gene Knockout Cell Lines represent a significant advancement in the realm of genetic research, specifically designed to facilitate the study of carbonic anhydrase 2 (CA2), a crucial enzyme involved in several physiological processes, including pH regulation and ion transport. These cell lines have been meticulously engineered using CRISPR/Cas9 technology to disrupt the CA2 gene, resulting in the absence of functional CA2 protein. This enables researchers to analyze the impact of CA2 absence on cellular functions, metabolic pathways, and disease models such as cancer, respiratory disorders, and metabolic syndromes.
The functionality of CA2 Gene Knockout Cell Lines hinges on their ability to mimic disease states by providing insights into the roles of CA2 under various experimental conditions. By employing these lines, researchers can elucidate the enzyme's involvement in acid-base homeostasis and bicarbonate transport, both critical factors in cellular behavior. Understanding these mechanisms is fundamental in disease research, as aberrations in CA2 expression and activity have been linked to various pathological conditions, making these cell lines invaluable in biomedical studies.
The scientific importance of utilizing CA2 Gene Knockout Cell Lines is underscored by their potential applications in drug discovery and development. By providing a reliable model to test therapeutic interventions, researchers can explore novel treatments targeting CA2-related pathways. Compared to traditional models, these knockout cell lines offer improved specificity and relevance, significantly enhancing experimental outcomes.
What sets CA2 Gene Knockout Cell Lines apart from alternatives is their precise genetic modification and the robust data generated from their use. Their consistent performance across multiple assays affords researchers a unique opportunity to explore complex biological interactions with confidence.
For researchers and clinicians alike, CA2 Gene Knockout Cell Lines represent a critical resource for advancing our understanding of carbonic anhydrase biology and its implications in health and disease. Enhancing research capabilities, these cell lines exemplify our commitment to providing cutting-edge solutions in the field of molecular biology. Our company specializes in developing high-quality biological products that empower the scientific community to accelerate their research endeavors and achieve groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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