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C5AR2 Knockout Cell Lines

Gene: C5AR2

Official Full Name: complement C5a receptor 2provided by HGNC

Gene Summary: This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06937 C5AR2 Knockout cell line (HeLa) Human C5AR2 1:3~1:6 Negative Online Inquiry

Background

C5AR2 Gene Knockout Cell Lines are specialized cellular models designed to study the function of the C5a receptor 2 (C5AR2) gene in various biological processes and disease states. C5AR2 is involved in immune responses and has implications in inflammatory diseases, cancer, and autoimmune disorders. The knockout cell lines effectively eliminate the expression of the C5AR2 gene, enabling researchers to investigate the signaling pathways and physiological responses that are altered when this receptor is absent.

The key function of these knockout cell lines lies in their ability to provide a controlled environment for the examination of C5AR2-related mechanisms. By observing the genetic and phenotypic consequences of the loss of this receptor, scientists can decipher its role in processes such as chemotaxis, cytokine secretion, and cell survival. The mechanism underpinning these studies often includes the assessment of changes in intracellular signaling cascades, gene expression profiles, and cellular behaviors, which are pivotal for understanding the receptor's contribution to health and disease.

The scientific importance of C5AR2 knockout cell lines extends to both research and clinical applications. In basic research, they help elucidate the pathophysiology of diseases mediated by the complement system and inform potential therapeutic targets. Clinically, insights gained from these models can lead to the development of novel anti-inflammatory agents and treatments for cancers where C5AR2 plays a critical role.

One of the unique selling points of our C5AR2 Gene Knockout Cell Lines is their high specificity and reliability, which surpasses many alternative models that do not provide a complete knockout. Their well-characterized background allows for reproducible results, thus enhancing the credibility of research findings. Furthermore, these cell lines are compatible with high-throughput screening methods and can be easily adapted for various applications, making them a highly flexible tool for investigators.

For researchers and clinicians seeking to deepen their understanding of C5AR2 function and its implications in disease, our knockout cell lines represent a valuable asset. They facilitate efficient experimentation and propel innovations in therapeutic development. Our company brings extensive expertise in producing high-quality gene knockout models and strives to support the scientific community with cutting-edge biological products tailored to advance research objectives.

Please note that all services are for research use only. Not intended for any clinical use.

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