Gene: C4B_2
Official Full Name: complement component 4B (Chido/Rodgers blood group), copy 2provided by HGNC
Gene Summary: This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. This GeneID and its associated RefSeq record represent a second copy of C4B found on ALT_REF_LOCI_7. [provided by RefSeq, Jul 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO19269 | C4B_2 Knockout cell line (HeLa) | Human | C4B_2 | 1:3~1:6 | Negative | Online Inquiry |
KO19270 | C4B_2 Knockout cell line (HCT 116) | Human | C4B_2 | 1:2~1:4 | Negative | Online Inquiry |
KO19271 | C4B_2 Knockout cell line (HEK293) | Human | C4B_2 | 1:3~1:6 | Negative | Online Inquiry |
KO19272 | C4B_2 Knockout cell line (A549) | Human | C4B_2 | 1:3~1:4 | Negative | Online Inquiry |
C4B_2 Gene Knockout Cell Lines are genetically modified cell lines designed to specifically disrupt the expression of the C4B gene, which plays a crucial role in various biological processes, including immune response and inflammation. These cell lines are created using advanced CRISPR-Cas9 technology, allowing for precise editing of the genomic sequence. By knocking out the C4B gene, researchers can investigate its function and elucidate pathways associated with diseases where C4B is implicated.
The primary mechanism of these knockout cell lines involves the targeted introduction of double-strand breaks in the DNA sequence of the C4B gene, followed by the cell’s natural repair processes, which often leads to mutations that effectively silence the gene. This allows for direct observation of alterations in cellular behavior, gene expression profiles, and biochemical pathways resulting from the absence of C4B, thereby facilitating a deeper understanding of its role in cellular contexts.
In terms of scientific significance, C4B_2 Gene Knockout Cell Lines are invaluable tools in biomedical research. They provide a reliable model to study autoimmune diseases, inflammatory conditions, and potential therapeutic targets. In clinical settings, these cell lines can be instrumental for developing personalized medicine approaches, enabling researchers to tailor treatments based on specific genetic profiles.
One of the primary advantages of C4B_2 Gene Knockout Cell Lines, compared to alternatives such as traditional knockout techniques or non-specific inhibitory methods, is their specificity and efficiency, helping to minimize off-target effects. Additionally, these cell lines are readily adaptable for high-throughput screening and can be utilized in various applications, including drug discovery and functional genomics.
Researchers and clinicians can greatly benefit from the precision and reliability of the C4B_2 Gene Knockout Cell Lines, which are essential for advancing our understanding of genetic mechanisms that underpin disease. Our company brings extensive expertise in gene editing technologies to provide top-quality products, ensuring robust research outcomes and aiding the global scientific community in pioneering discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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