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C4BPB Knockout Cell Lines

Gene: C4BPB

Official Full Name: complement component 4 binding protein betaprovided by HGNC

Gene Summary: This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38757 C4BPB Knockout cell line (HeLa) Human C4BPB 1:3~1:6 Negative Online Inquiry
KO38758 C4BPB Knockout cell line (A549) Human C4BPB 1:3~1:4 Negative Online Inquiry

Background

C4BPB Gene Knockout Cell Lines are a cutting-edge biological tool specifically engineered for the study of the complement system and its role in immune regulation. This product consists of a series of cell lines where the C4BPB gene has been systematically disrupted using CRISPR-Cas9 technology, resulting in targeted gene knockout. These modified cell lines provide a controlled environment to investigate the biological consequences of C4BPB loss, including alterations in complement activation pathways, immune response modulation, and implications for various pathological conditions.

The key functions of C4BPB Gene Knockout Cell Lines lie in their ability to mimic specific genetic scenarios, allowing researchers to delve into the functional diversity of complement proteins and their involvement in immune responses. The absence of C4BPB alters complement activity, which can significantly affect cellular behaviors, inflammation, and pathogen recognition. Consequently, these models are invaluable for elucidating the biological mechanisms underpinning diseases such as autoimmune disorders, infections, and cancers.

The scientific importance of these cell lines extends into both research and clinical applications. They facilitate high-throughput screening of therapeutic agents that target complement pathways, enhance our understanding of immune evasion strategies employed by pathogens, and serve as a platform for personalized medicine approaches in developing complement-targeted therapies.

Compared to traditional cell lines, the specificity of C4BPB knockout enables more precise and reproducible results, reducing background noise from other complement components. This specificity provides a significant advantage in enhancing the reliability of experimental data and fosters innovative research in immunology and related fields.

For researchers, clinicians, and biotechnology firms, the C4BPB Gene Knockout Cell Lines represent a critical asset for advancing the understanding of immune regulation. As researchers continue to explore the intricacies of the immune system, these specialized cell lines help illuminate paths toward novel diagnostics and therapeutics.

Our company prides itself on its expertise in the development of high-quality, genetically modified cell lines tailored for cutting-edge research. With a commitment to empowering scientific discovery, we ensure that our products meet the highest standards of accuracy and reliability, enabling researchers to achieve their goals with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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