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C3ar1 Knockout Cell Lines

Gene: C3ar1

Official Full Name: complement component 3a receptor 1provided by MGI

Gene Summary: Predicted to enable G protein-coupled receptor activity; complement component C3a binding activity; and complement receptor activity. Involved in positive regulation of angiogenesis; positive regulation of vascular endothelial growth factor production; and regulation of granulocyte chemotaxis. Predicted to be active in plasma membrane. Is expressed in several structures, including bladder; blood; cerebral cortex; gut; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in asthma. Orthologous to human C3AR1 (complement C3a receptor 1). [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01250 C3ar1 Knockout cell line (RAW 264.7) Mouse C3ar1 Negative Online Inquiry

Background

C3ar1 Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to lack the expression of the C3ar1 gene, which encodes the complement component 3a receptor 1 involved in immune response regulation. These knockout cell lines are powerful tools for studying the functional role of C3ar1 in various biological processes, including inflammation, immune cell signaling, and tissue homeostasis. By eliminating the C3ar1 gene, researchers are provided with a precise platform to investigate the receptor's influence on cellular behavior, response to pathogens, and potential implications in diseases such as autoimmune disorders and cancer.

The foundational mechanism of these knockout lines lies in CRISPR/Cas9 genome editing technology, which enables targeted disruption of the C3ar1 gene. This advanced technique allows scientists to create a precise deletion, ensuring that the modified cell lines lack not only the protein but also any downstream signaling pathways influenced by C3ar1. In both research and clinical settings, these cell lines are invaluable for drug discovery, enabling pharmaceutical companies and academic labs to evaluate the potential of new therapeutics that modulate the immune system through the C3a receptor.

One of the significant advantages of C3ar1 Gene Knockout Cell Lines is their specificity in addressing the role of the C3ar1 receptor, which distinguishes them from less focused models that may offer a broader, less conclusive view of immune signaling pathways. This targeted approach enhances experimental reproducibility and reliability, making it easier for researchers to draw clear conclusions. Additionally, the availability of these cell lines streamlines the validation process for compounds intended for clinical use, thereby accelerating the pace of research and development.

For researchers and clinicians pursuing innovative solutions in immunology, these cell lines represent a critical asset. They not only aid in elucidating complex pathways associated with immune responses but also serve as a reliable model for testing therapeutic hypotheses. At our company, we are dedicated to advancing scientific understanding and product development by providing high-quality, expertly engineered biological tools. Our commitment to innovation and excellence in genetic models positions us as a leading provider in the field, ensuring that researchers have access to cutting-edge resources critical to their studies.

Please note that all services are for research use only. Not intended for any clinical use.

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