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BTN2A2 Knockout Cell Lines

Gene: BTN2A2

Official Full Name: butyrophilin subfamily 2 member A2provided by HGNC

Gene Summary: Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31919 BTN2A2 Knockout cell line (HeLa) Human BTN2A2 1:3~1:6 Negative Online Inquiry
KO31920 BTN2A2 Knockout cell line (HCT 116) Human BTN2A2 1:2~1:4 Negative Online Inquiry
KO31921 BTN2A2 Knockout cell line (HEK293) Human BTN2A2 1:3~1:6 Negative Online Inquiry
KO31922 BTN2A2 Knockout cell line (A549) Human BTN2A2 1:3~1:4 Negative Online Inquiry

Background

BTN2A2 Gene Knockout Cell Lines are specially engineered cellular models in which the BTN2A2 gene has been purposefully disrupted, providing a powerful tool for studying gene function and regulation. By utilizing precision genome editing techniques such as CRISPR/Cas9, these cell lines allow researchers to investigate the consequences of BTN2A2 deletion on cellular behavior, signaling pathways, and phenotypic outcomes, enabling a deeper understanding of various biological processes.

The knockout mechanism specifically silences the BTN2A2 gene, which encodes a member of the B7 family of immune-regulatory molecules. This perturbation can reveal crucial insights into immune response modulation, dendritic cell function, and tumor immune evasion. In clinical research, exploring the role of BTN2A2 can lead to advancements in cancer immunotherapy by highlighting how tumors exploit this pathway to avoid immune detection.

Compared to traditional methods of gene manipulation, our BTN2A2 Knockout Cell Lines offer unique advantages such as enhanced reproducibility and specificity in experimental setups. The precise gene targeting minimizes off-target effects, thereby improving the validity of research findings and facilitating more reliable results. Additionally, these cell lines are readily available and easy to culture, allowing for straightforward integration into existing laboratory workflows.

For researchers and clinicians, the BTN2A2 Knockout Cell Lines stand as an invaluable resource for unraveling complex cellular interactions, ultimately driving innovative therapeutic strategies. By equipping scientists with high-quality, accurately characterized cell lines, our company empowers the research community to push the boundaries of knowledge in immunology and cancer biology. With our expertise in developing cutting-edge biological products, we are committed to supporting advancement in life sciences research and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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