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BTD Knockout Cell Lines

Gene: BTD

Official Full Name: biotinidaseprovided by HGNC

Gene Summary: The protein encoded by this gene functions to recycle protein-bound biotin by cleaving biocytin (biotin-epsilon-lysine), a normal product of carboxylase degradation, resulting in regeneration of free biotin. The encoded protein has also been shown to have biotinyl transferase activity. Mutations in this gene are associated with biotinidase deficiency. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38771 BTD Knockout cell line (HeLa) Human BTD 1:3~1:6 Negative Online Inquiry
KO38772 BTD Knockout cell line (HCT 116) Human BTD 1:2~1:4 Negative Online Inquiry
KO38773 BTD Knockout cell line (HEK293) Human BTD 1:3~1:6 Negative Online Inquiry
KO38774 BTD Knockout cell line (A549) Human BTD 1:3~1:4 Negative Online Inquiry

Background

BTD Gene Knockout Cell Lines are genetically modified cellular models that lack the expression of the Biotinidase (BTD) gene, a critical enzyme responsible for recycling biotin within the human body. These cell lines serve as invaluable tools for investigating the functional role of biotin in cellular metabolism and understanding the implications of its deficiency, particularly in the context of various genetic disorders associated with impaired biotin metabolism.

The primary function of BTD Gene Knockout Cell Lines lies in their ability to provide a controlled environment for researchers to explore the phenotypic consequences of BTD gene depletion. By observing the cellular processes and metabolic pathways altered in the absence of biotin recycling, scientists can elucidate the biochemical mechanisms underlying biotin-related diseases. Moreover, these cell lines can be utilized in drug discovery and development initiatives, aiding in the identification of therapeutic strategies that target metabolic dysregulation caused by biotinidase deficiency.

From a scientific standpoint, BTD Gene Knockout Cell Lines hold significant importance in research settings, particularly for studies focusing on metabolic disorders, nutritional biochemistry, and gene therapy. Their application extends to clinical research, where understanding genetic variances can lead to tailored interventions for affected individuals.

Compared to alternative models, such as wild-type or non-targeted cell lines, BTD Gene Knockout Cell Lines provide specificity and relevance in biotin research. Their targeted genetic modification allows for precise investigations, reducing background noise and improving experimental outcomes. The distinct advantages of utilizing these specialized cell lines include enhanced reproducibility of results and a greater understanding of gene-environment interactions in metabolic pathways.

Researchers and clinicians can find immense value in BTD Gene Knockout Cell Lines, as they not only contribute to a deeper understanding of biotin metabolism but also lay the groundwork for potential advancements in clinical diagnostics and therapeutics. The use of these cell lines empowers scientists to develop innovative approaches for managing biotin-related disorders, ultimately benefiting patient care.

Our company specializes in providing high-quality biological products backed by extensive research and development. With a commitment to advancing scientific knowledge, we offer a range of innovative solutions, including our BTD Gene Knockout Cell Lines, to support researchers and clinicians in their quest for breakthroughs in biological science.

Please note that all services are for research use only. Not intended for any clinical use.

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