Gene: BSPRY
Official Full Name: B-box and SPRY domain containingprovided by HGNC
Gene Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cell leading edge; membrane; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO19365 | BSPRY Knockout cell line (HCT 116) | Human | BSPRY | 1:2~1:4 | Negative | Online Inquiry |
KO19366 | BSPRY Knockout cell line (HEK293) | Human | BSPRY | 1:3~1:6 | Negative | Online Inquiry |
BSPRY Gene Knockout Cell Lines are genetically modified cellular models that facilitate the study of the biological roles of the BSPRY gene by eliminating its expression. This innovative tool harnesses CRISPR-Cas9 technology to create precise gene deletions, offering researchers a definitive method to analyze the functional consequences of BSPRY gene loss. The primary mechanism of action involves the introduction of double-strand breaks at targeted nucleotide sequences within the gene, which are subsequently repaired by non-homologous end joining. This repair process often results in insertions or deletions that render the gene nonfunctional, providing a cell line that accurately represents the absence of BSPRY activity.
The scientific importance of BSPRY Gene Knockout Cell Lines lies in their capacity to model various diseases associated with aberrant BSPRY expression, including certain cancers and inflammatory conditions. In clinical research, these cell lines serve as valuable tools for drug discovery, target validation, and understanding disease pathology stemming from gene dysregulation. Researchers utilize these models to screen for therapeutic compounds that may restore normal cellular function or modulate disease pathways.
What sets BSPRY Gene Knockout Cell Lines apart from alternative models is their specificity and ease of use. Unlike traditional methods such as siRNA knockdowns, which can produce transient effects and off-target effects, CRISPR-based knockouts ensure stable gene disruption for long-term studies. Additionally, these cell lines are rigorously characterized to ensure a consistent and reproducible cellular background.
Investing in BSPRY Gene Knockout Cell Lines is invaluable for researchers and clinicians seeking to unveil the complexities of gene function in a controlled environment. Utilizing these cells not only accelerates the discovery process but also enhances the reliability of experimental outcomes. Furthermore, our company, with a strong emphasis on cutting-edge genetic engineering and deep expertise in molecular biology, is committed to providing high-quality biological products that empower the scientific community to advance their research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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