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BSCL2 Knockout Cell Lines

Gene: BSCL2

Official Full Name: BSCL2 lipid droplet biogenesis associated, seipinprovided by HGNC

Gene Summary: This gene encodes the multi-pass transmembrane protein seipin. This protein localizes to the endoplasmic reticulum and may be important for lipid droplet morphology. Mutations in this gene have been associated with congenital generalized lipodystrophy type 2 or Berardinelli-Seip syndrome, a rare autosomal recessive disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U-like 2).[provided by RefSeq, Jul 2024]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05426 BSCL2 Knockout cell line (HeLa) Human BSCL2 1:3~1:6 Negative Online Inquiry
KO05427 BSCL2 Knockout cell line (HCT 116) Human BSCL2 1:2~1:4 Negative Online Inquiry
KO05428 BSCL2 Knockout cell line (HEK293) Human BSCL2 1:3~1:6 Negative Online Inquiry
KO05429 BSCL2 Knockout cell line (A549) Human BSCL2 1:3~1:4 Negative Online Inquiry

Background

BSCL2 Gene Knockout Cell Lines are genetically modified cellular models designed for the targeted deletion of the BSCL2 gene, which encodes a protein implicated in lipid metabolism and cellular stress responses. These knockout cell lines serve as essential tools for studying the gene's role in various biological processes and its contributions to diseases such as lipodystrophy and metabolic syndrome.

The primary function of these knockout cell lines is to facilitate the investigation of BSCL2-mediated pathways in a controlled environment, allowing scientists to elucidate how gene disruption affects cellular function, lipid storage, and response to stress conditions. By generating a precise deletion of the BSCL2 gene, researchers can observe the resulting phenotypic changes and identify downstream signaling pathways that may contribute to the pathological features associated with its dysfunction.

In terms of scientific importance, BSCL2 Gene Knockout Cell Lines are invaluable in both research and clinical settings. They enable researchers to model human diseases more accurately, allowing for the screening of potential therapeutic compounds and the exploration of novel treatment strategies. Additionally, they contribute to the broader understanding of lipid metabolism disorders, a growing area of interest in metabolic disease research.

What sets our BSCL2 Gene Knockout Cell Lines apart from alternatives is the high specificity and efficiency of the gene editing process used to create them, resulting in a reliable model for reproducibility in experiments. Our cell lines are validated through rigorous phenotypic and genotypic characterization, providing users with confidence in their experimental outcomes.

For researchers, clinicians, and pharmaceutical developers, these knockout models represent a vital resource for advancing the understanding of BSCL2's biological roles. Beyond offering high-quality biological products, our company prides itself on delivering exceptional customer support and guidance, backed by years of expertise in the field of genetic engineering and cell line development. Our commitment ensures that users receive both the products and the resources necessary to succeed in their research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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