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BRAT1 Knockout Cell Lines

Gene: BRAT1

Official Full Name: BRCA1 associated ATM activator 1provided by HGNC

Gene Summary: The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00152 BRAT1 Knockout cell line (HeLa) Human BRAT1 1:3~1:6 Negative Online Inquiry
KO39159 BRAT1 Knockout cell line (HCT 116) Human BRAT1 1:2~1:4 Negative Online Inquiry
KO39160 BRAT1 Knockout cell line (HEK293) Human BRAT1 1:3~1:6 Negative Online Inquiry
KO39161 BRAT1 Knockout cell line (A549) Human BRAT1 1:3~1:4 Negative Online Inquiry

Background

BRAT1 Gene Knockout Cell Lines are genetically modified cellular models designed to lack expression of the BRAT1 gene, a pivotal component in the regulation of cellular responses to DNA damage and cellular signaling pathways. By employing advanced CRISPR/Cas9 gene-editing technology, these cell lines provide a precise and efficient means of studying the biological functions associated with BRAT1 deficiency, thereby elucidating its role in various cellular processes, such as cell cycle regulation, apoptosis, and DNA repair mechanisms.

The primary function of the BRAT1 Gene Knockout Cell Lines is to serve as a valuable tool for researchers investigating the implications of BRAT1 in various pathologies, including neurodegenerative disorders and cancer. The knockout of this gene allows researchers to observe the physiological changes and molecular pathways activated in its absence, leading to a deeper understanding of how aberrations in BRAT1 can contribute to disease pathology. This is particularly important in the context of personalized medicine, where understanding gene function can directly impact therapeutic strategies.

In comparison to traditional cell lines or approaches, the BRAT1 Gene Knockout Cell Lines offer distinct advantages, such as enhanced specificity in studying gene function and the potential for high-throughput screening applications. These knockout models enable researchers to implement targeted experiments with greater precision and reproducibility.

This product stands out due to its robust validation and the ease of use it provides for a wide range of experimental designs, ensuring that researchers can confidently obtain meaningful data related to BRAT1. As a result, these cell lines are invaluable to both basic research and clinical applications, including drug discovery and treatment development.

Our company specializes in providing high-quality biological products with a focus on cutting-edge gene-editing technologies. We are committed to supporting the scientific community by offering robust, reliable research tools that facilitate groundbreaking discoveries and advancements in biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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