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BOLA3 Knockout Cell Lines

Gene: BOLA3

Official Full Name: bolA family member 3provided by HGNC

Gene Summary: This gene encodes a protein that plays an essential role in the production of iron-sulfur (Fe-S) clusters for the normal maturation of lipoate-containing 2-oxoacid dehydrogenases, and for the assembly of the mitochondrial respiratory chain complexes. Mutation in this gene has been associated with multiple mitochondrial dysfunctions syndrome-2. Two alternatively spliced transcript variants encoding different isoforms with distinct subcellular localization have been reported for this gene (PMID:21944046). [provided by RefSeq, Dec 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19390 BOLA3 Knockout cell line (HeLa) Human BOLA3 1:3~1:6 Negative Online Inquiry
KO19391 BOLA3 Knockout cell line (HCT 116) Human BOLA3 1:2~1:4 Negative Online Inquiry
KO19392 BOLA3 Knockout cell line (HEK293) Human BOLA3 1:3~1:6 Negative Online Inquiry
KO19393 BOLA3 Knockout cell line (A549) Human BOLA3 1:3~1:4 Negative Online Inquiry

Background

BOLA3 Gene Knockout Cell Lines are genetically engineered cellular models that have been specifically designed to study the functional role of the BOLA3 gene, which is implicated in cellular processes such as protein homeostasis and mitochondrial integrity. These cell lines are created using advanced CRISPR-Cas9 gene-editing technology, allowing for precise deletion of the BOLA3 gene, thereby providing researchers with the ability to assess the consequent phenotypic changes and molecular pathways affected by its absence.

The key function of BOLA3 Gene Knockout Cell Lines is to facilitate investigations into the gene's role in various biological processes, including essential functions in cellular metabolism, apoptosis, and stress responses. By utilizing these knockout models, scientists can elucidate the mechanisms underlying diseases associated with BOLA3 dysregulation, such as neurodegenerative disorders or metabolic syndromes. This makes them invaluable in both basic and applied research settings, where understanding gene function is crucial for developing targeted therapies.

One of the unique advantages of using BOLA3 Gene Knockout Cell Lines lies in their specificity and reliability compared to traditional knockout methods. The CRISPR-Cas9 approach ensures high targeting efficiency and minimal off-target effects, producing cell lines with consistent knockout characteristics that are essential for reproducibility in scientific experiments. Moreover, these knockout models allow for high-throughput screening of potential therapeutic compounds, streamlining the discovery process in drug development.

For researchers and clinicians investigating the role of BOLA3 in pathology or pharmacology, these cell lines represent a powerful tool. Their ability to mimic disease conditions more accurately than standard cell lines enhances the relevance of experimental findings, accelerating advancements in clinical applications.

At our company, we pride ourselves on our expertise in developing cutting-edge biological products such as BOLA3 Gene Knockout Cell Lines. Our commitment to rigorously validated, high-quality models empowers researchers to push the boundaries of science and improve therapeutic outcome strategies.

Please note that all services are for research use only. Not intended for any clinical use.

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