Gene: BLOC1S6
Official Full Name: biogenesis of lysosomal organelles complex 1 subunit 6provided by HGNC
Gene Summary: The protein encoded by this gene may play a role in intracellular vesicle trafficking. It interacts with Syntaxin 13 which mediates intracellular membrane fusion. Mutations in this gene cause symptoms associated with Hermansky-Pudlak syndrome-9. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome. [provided by RefSeq, Aug 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28179 | BLOC1S6 Knockout cell line (HeLa) | Human | BLOC1S6 | 1:3~1:6 | Negative | Online Inquiry |
KO28180 | BLOC1S6 Knockout cell line (HCT 116) | Human | BLOC1S6 | 1:2~1:4 | Negative | Online Inquiry |
KO28181 | BLOC1S6 Knockout cell line (HEK293) | Human | BLOC1S6 | 1:3~1:6 | Negative | Online Inquiry |
KO28182 | BLOC1S6 Knockout cell line (A549) | Human | BLOC1S6 | 1:3~1:4 | Negative | Online Inquiry |
BLOC1S6 Gene Knockout Cell Lines are genetically modified cell lines designed for the functional study of the BLOC1S6 gene, a critical component of the biogenesis of lysosome-related organelles. Through a precise gene-editing technique, these knockout cell lines enable researchers to investigate the resultant phenotypic changes following the loss of BLOC1S6 expression, thereby elucidating its role in cellular processes such as endosomal trafficking and pigmentation pathways.
The key mechanism underlying the functionality of these cell lines lies in the selective disruption of the BLOC1S6 gene, achieved via CRISPR/Cas9 technology. This precise editing creates a cellular model where the normal expression of BLOC1S6 is ablated, serving as a vital tool for researchers aiming to decode the gene's contributions to various pathophysiological conditions, including neurodegenerative diseases and certain forms of inherited syndromes.
Scientifically, BLOC1S6 Gene Knockout Cell Lines hold substantial importance for both academic and clinical research settings, facilitating groundbreaking studies into organelle dysfunctions and their implications in disease. The ability to create a controlled environment in which the effects of gene loss can be measured offers unparalleled insights into the underlying pathogenic mechanisms.
Distinctively, these knockout cell lines provide advantages over traditional methods that often rely on transient gene silencing, which can produce variable and transient effects. The stable knockout ensures reproducibility across experiments, making them more reliable for longitudinal studies. Additionally, the specificity of the knockout offers a clarity that can often be obscured in broader genomic manipulation approaches.
Researchers and clinicians alike will find these cell lines invaluable as they seek to unravel the complexities of gene function in health and disease, potentially leading to novel therapeutic strategies. Our company, with its expertise in cutting-edge genetic engineering techniques, is committed to providing high-quality biological products, such as the BLOC1S6 Gene Knockout Cell Lines, designed to advance scientific research and discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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