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BCOR Knockout Cell Lines

Gene: BCOR

Official Full Name: BCL6 corepressorprovided by HGNC

Gene Summary: The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20845 BCOR Knockout cell line (HeLa) Human BCOR 1:3~1:6 Negative Online Inquiry
KO20846 BCOR Knockout cell line (HCT 116) Human BCOR 1:2~1:4 Negative Online Inquiry
KO20847 BCOR Knockout cell line (HEK293) Human BCOR 1:3~1:6 Negative Online Inquiry
KO20848 BCOR Knockout cell line (A549) Human BCOR 1:3~1:4 Negative Online Inquiry

Background

BCOR Gene Knockout Cell Lines represent a pivotal advancement in genetic research, specifically designed to elucidate the functional role of the BCL6 Corepressor (BCOR) gene in various biological processes and disease states. These custom-engineered cell lines utilize CRISPR/Cas9 technology to achieve specific and targeted gene deletion, allowing researchers to dissect the contributions of BCOR to cellular pathways, differentiation, and apoptosis.

The primary function of the BCOR Gene Knockout Cell Lines is to provide a controlled environment in which the effects of the loss of BCOR expression can be comprehensively studied. By creating a model that mimics gene dysfunction, researchers can investigate mechanisms of disease, such as hematological malignancies and solid tumors, where dysregulation of BCOR has been implicated. The ability to observe phenotypic changes, gene expression alterations, and signaling pathway modifications in these cell lines enhances our understanding of the gene's role in tumorigenesis and offers insights for therapeutic strategies.

In both research and clinical settings, BCOR Gene Knockout Cell Lines are invaluable tools that bridge the gap between basic science and applied medicine. They facilitate investigations into new drug targets and biomarkers, ultimately leading to innovative treatment approaches in oncology and regenerative medicine. Compared to alternative methods, such as RNA interference or transient transfection approaches that may lack specificity or stability, the precision of CRISPR/Cas9 knockouts offers robust and reproducible results.

Researchers and clinicians can derive significant value from BCOR Gene Knockout Cell Lines as they explore the complexities of gene functions and interactions within cellular systems. These cell lines can drastically improve experimental planning and outcomes, ensuring that studies yield meaningful insights that are translatable to real-world applications.

At [Your Company Name], we pride ourselves on our commitment to providing high-quality biological products, supported by extensive expertise in genetic engineering and molecular biology. With our state-of-the-art technologies and a team dedicated to advancing scientific understanding, we empower researchers to push the boundaries of knowledge in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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