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BCL9L Knockout Cell Lines

Gene: BCL9L

Official Full Name: BCL9 likeprovided by HGNC

Gene Summary: Enables beta-catenin binding activity. Involved in several processes, including negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of epithelial to mesenchymal transition; and positive regulation of transcription by RNA polymerase II. Located in fibrillar center and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20516 BCL9L Knockout cell line (HeLa) Human BCL9L 1:3~1:6 Negative Online Inquiry
KO20517 BCL9L Knockout cell line (HCT 116) Human BCL9L 1:2~1:4 Negative Online Inquiry
KO20518 BCL9L Knockout cell line (HEK293) Human BCL9L 1:3~1:6 Negative Online Inquiry
KO20519 BCL9L Knockout cell line (A549) Human BCL9L 1:3~1:4 Negative Online Inquiry

Background

BCL9L Gene Knockout Cell Lines are specialized cellular models created through advanced gene-editing techniques, specifically utilizing CRISPR/Cas9 technology. These cell lines have been meticulously engineered to silence the BCL9L gene, which plays a crucial role in the Wnt signaling pathway and has been implicated in various pathologies, including cancers and developmental disorders. By disrupting the expression of BCL9L, researchers can investigate the gene's function and its impact on cellular processes, enabling a deeper understanding of oncogenic mechanisms and potential therapeutic targets.

The key function of BCL9L Gene Knockout Cell Lines lies in their ability to serve as powerful tools for elucidating the intricate molecular interactions involved in Wnt signaling. By examining these knockouts, scientists can study changes in cell proliferation, differentiation, and apoptosis, while also assessing the effects on downstream signaling pathways. This facilitates the identification of novel drug targets and biomarker discovery, which are pivotal in advancing personalized medicine approaches.

In both research and clinical settings, these cell lines are invaluable for preclinical studies, drug screening, and the validation of new therapeutic strategies. They present researchers with a reliable model that mimics in vivo conditions, thereby enhancing the translatability of findings to human biology. Compared to alternative models, BCL9L Gene Knockout Cell Lines provide a more precise and targeted approach to studying specific gene functions, ultimately leading to more informed and effective therapeutic interventions.

The value of BCL9L Gene Knockout Cell Lines extends beyond just their experimental utility; they also empower researchers and clinicians to unlock biological insights that drive innovation in treatment options. Our company specializes in developing high-quality biological products that facilitate robust scientific inquiry. With our expertise in gene editing and cell line development, we are committed to providing exceptional tools that meet the evolving needs of the scientific community, ensuring that your research can achieve its highest potential.

Please note that all services are for research use only. Not intended for any clinical use.

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