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BCL3 Knockout Cell Lines

Gene: BCL3

Official Full Name: BCL3 transcription coactivatorprovided by HGNC

Gene Summary: This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08326 BCL3 Knockout cell line (HeLa) Human BCL3 1:3~1:6 Negative Online Inquiry
KO08327 BCL3 Knockout cell line (HCT 116) Human BCL3 1:2~1:4 Negative Online Inquiry
KO08328 BCL3 Knockout cell line (A549) Human BCL3 1:3~1:4 Negative Online Inquiry

Background

BCL3 Gene Knockout Cell Lines are specialized cell models engineered to lack the expression of the BCL3 gene, which encodes a nuclear protein implicated in the regulation of immune response, cell proliferation, and oncogenesis. This precise genetic modification allows researchers to study the role of BCL3 in various biological processes, offering insights into its function in cancer biology, inflammation, and cell signaling pathways.

These knockout cell lines function through the strategic disruption of BCL3 expression, providing a tool for dissecting the molecular mechanisms by which BCL3 contributes to cellular behavior. Researchers can use these cell lines to explore the effects of BCL3 deficiency on cell cycle regulation, apoptosis, and response to external stimuli, facilitating a deeper understanding of its pathogenic role in diseases such as leukemia and solid tumors.

The scientific importance of BCL3 Gene Knockout Cell Lines lies in their applications across translational and basic research. They can serve as invaluable models to assess therapeutic targets and validate hypotheses related to BCL3's involvement in disease mechanisms. Clinicians can also leverage these models to inform the development of targeted therapies aimed at modulating BCL3 activity.

One of the primary advantages of our BCL3 Gene Knockout Cell Lines is their consistency and reproducibility, which are crucial for reliable experimental results. Compared to alternative models, these cell lines provide a precise knockout approach that avoids the complications associated with transient knockdown methods, making them ideal for long-term studies. Additionally, our product comes with extensive characterization data, ensuring researchers can trust the functionality and specificity of the BCL3 knockout.

Overall, these knockout cell lines represent a powerful asset for researchers and clinicians seeking to elucidate the role of BCL3 in human health and disease. Our company has a proven track record in providing high-quality biological products and resources, equipping scientists with the tools they need to advance their research and improve clinical outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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