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BCAT1 Knockout Cell Lines

Gene: BCAT1

Official Full Name: branched chain amino acid transaminase 1provided by HGNC

Gene Summary: This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00216 BCAT1 gRNA1-gRNA2 KO plasmid BCAT1 $850
KO00638 BCAT1 Knockout cell line(Hep G2) Human BCAT1 1:2~1:4 Negative Online Inquiry
KO00639 BCAT1 Knockout cell line(Huh-7) Human BCAT1 1:2~1:3 Negative Online Inquiry
KO04137 BCAT1 Knockout cell line (HeLa) Human BCAT1 1:3~1:6 Negative Online Inquiry
KO04138 BCAT1 Knockout cell line (HEK293) Human BCAT1 1:3~1:6 Negative Online Inquiry
KO04139 BCAT1 Knockout cell line (A549) Human BCAT1 1:3~1:4 Negative Online Inquiry

Background

BCAT1 Gene Knockout Cell Lines are meticulously engineered cell lines in which the BCAT1 gene has been intentionally disrupted, allowing researchers to study the gene's specific functions and its contributions to various biological processes. Catalyzing the conversion of branched-chain amino acids, BCAT1 is implicated in amino acid metabolism, neurotransmitter synthesis, and cancer biology. By utilizing these knockout lines, scientists can explore the metabolic pathways and signaling cascades affected by the absence of BCAT1, leading to a more profound understanding of cellular physiology under various experimental conditions.

Functionally, these knockout cell lines operate without the regulatory influence of BCAT1, enabling researchers to observe the resultant alterations in metabolic flux, cell proliferation, and differentiation. This provides a powerful model to investigate the role of BCAT1 in diseases, particularly in tumefaction, where aberrant metabolic pathways are a hallmark. Additionally, the utility of these cell lines extends to drug discovery, facilitating the evaluation of therapeutic agents targeting metabolism-linked diseases.

The scientific importance of BCAT1 Gene Knockout Cell Lines lies in their application within both basic and translational research settings. They have established themselves as invaluable tools to elucidate the mechanistic underpinnings of various pathologies where BCAT1 is implicated, including neurological disorders and cancers. Compared to traditional cell lines, these genetic knockouts provide a more precise model of BCAT1 functionality, avoiding the confounding effects that can arise from non-targeted genetic manipulations.

A significant advantage of BCAT1 Gene Knockout Cell Lines is their specificity and reproducibility. By offering a consistent and controlled environment for experiments, they enhance the reliability of experimental outcomes, which is critical in research settings where precision is paramount. Researchers and clinicians can therefore leverage these cell lines to develop targeted therapies with the potential for higher efficacy and lower side effects.

Our company prides itself on its expertise in genetic engineering and cell line development, providing high-quality products that serve the research community's evolving needs. We are committed to supporting scientific advancements by supplying researchers with innovative tools, such as the BCAT1 Gene Knockout Cell Lines, that drive discovery and therapeutic development forward.

Please note that all services are for research use only. Not intended for any clinical use.

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