Gene: BAZ2A
Official Full Name: bromodomain adjacent to zinc finger domain 2Aprovided by HGNC
Gene Summary: Enables histone binding activity. Contributes to RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in DNA methylation-dependent constitutive heterochromatin formation; negative regulation of transcription by RNA polymerase I; and rDNA heterochromatin formation. Predicted to act upstream of or within heterochromatin formation. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31124 | BAZ2A Knockout cell line (HeLa) | Human | BAZ2A | 1:3~1:6 | Negative | Online Inquiry |
KO31125 | BAZ2A Knockout cell line (HCT 116) | Human | BAZ2A | 1:2~1:4 | Negative | Online Inquiry |
KO31126 | BAZ2A Knockout cell line (HEK293) | Human | BAZ2A | 1:3~1:6 | Negative | Online Inquiry |
KO31127 | BAZ2A Knockout cell line (A549) | Human | BAZ2A | 1:3~1:4 | Negative | Online Inquiry |
BAZ2A Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to study the functional role of the BAZ2A gene, known for its involvement in chromatin remodeling and regulation of gene expression. These cell lines have been meticulously developed using CRISPR/Cas9 technology to create precise deletions in the BAZ2A gene, enabling researchers to explore the phenotypic consequences of its absence.
The key functions of BAZ2A include its binding to acetylated histones, which plays a critical role in modulating chromatin structure and influencing transcriptional activity. By utilizing the BAZ2A Gene Knockout Cell Lines, scientists can investigate the gene's effects on various biological processes, including cell proliferation, differentiation, and response to external stimuli. This knockout model is particularly valuable for understanding the molecular mechanisms underlying diseases where BAZ2A dysfunction may be implicated, such as cancers or developmental disorders.
In the realm of biomedical research, these cell lines offer significant advantages over traditional models, including enhanced specificity and the ability to eliminate off-target effects typically associated with earlier genetic modification techniques. Researchers can achieve more reliable and reproducible results when conducting functional assays, thereby accelerating the discovery of novel therapeutic targets.
The BAZ2A Gene Knockout Cell Lines stand out due to their robustness and versatility, making them an essential tool for both basic and translational research. These cell lines empower scientists to uncover pivotal insights into gene function and its implications in health and disease, providing a valuable resource for both academic and pharmaceutical researchers.
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Please note that all services are for research use only. Not intended for any clinical use.
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