Gene: BACH2
Official Full Name: BTB domain and CNC homolog 2provided by HGNC
Gene Summary: Enables sequence-specific double-stranded DNA binding activity. Involved in primary adaptive immune response involving T cells and B cells. Located in cytosol and nucleoplasm. Part of RNA polymerase II transcription regulator complex. Implicated in immunodeficiency 60. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01722 | BACH2 Knockout cell line (HCT 116) | Human | BACH2 | 1:2~1:4 | Negative | Online Inquiry |
KO01723 | BACH2 Knockout cell line (HEK293) | Human | BACH2 | 1:3~1:6 | Negative | Online Inquiry |
BACH2 Gene Knockout Cell Lines are innovative biological tools engineered to study the functional role of the BACH2 gene within various cellular contexts. BACH2 is a crucial transcription factor involved in the regulation of immune responses and the development of B cells. By utilizing CRISPR-Cas9 technology to create knockout cell lines, these products enable researchers to investigate the gene’s specific contributions to immune function and its implications in pathological conditions, such as autoimmune diseases and cancers.
The key mechanism of the BACH2 Gene Knockout Cell Lines lies in the targeted disruption of the BACH2 gene, effectively inactivating its expression. This allows for the examination of downstream effects on cellular pathways, including those governing cell maturation, proliferation, and differentiation. Researchers can elucidate BACH2's role by conducting comparative studies with wild-type cell lines, thereby providing insights into its regulatory functions.
The scientific importance of these knockout cell lines is underscored by their applications in both fundamental and translational research. They serve as critical models for understanding BACH2's role in immunological processes and the development of novel therapeutic strategies. Furthermore, they can assist in determining responses to immunotherapies and the development of targeted therapeutics for immune-related disorders.
Compared to alternative experimental approaches, BACH2 Gene Knockout Cell Lines offer a precision-driven method to explore gene functions. Traditional methods, such as pharmacological inhibition or transgenic models, may not fully recapitulate gene loss’s effects. In contrast, these knockout lines provide a clean genetic background, reducing confounding variables and enabling clearer interpretations of results.
For researchers and clinicians seeking to advance their studies in immunology or cancer biology, BACH2 Gene Knockout Cell Lines hold substantial value. They represent not just a tool for basic research but are pivotal in shaping our understanding of disease mechanisms and potential therapeutic avenues.
Our company is committed to delivering high-quality biological products that empower scientific discovery. With a focus on innovation and reliability, we provide researchers with the tools needed to unlock the complexities of gene function and regulation.
Please note that all services are for research use only. Not intended for any clinical use.
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