Gene: B4GALT6
Official Full Name: beta-1,4-galactosyltransferase 6provided by HGNC
Gene Summary: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes in human. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. This gene produces multiple protein isoforms - some of which are predicted to lack the N-terminal hydrophobic signal sequence and transmembrane domain. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The canonical enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis. [provided by RefSeq, Jan 2020]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33321 | B4GALT6 Knockout cell line (HCT 116) | Human | B4GALT6 | 1:2~1:4 | Negative | Online Inquiry |
KO33322 | B4GALT6 Knockout cell line (HEK293) | Human | B4GALT6 | 1:3~1:6 | Negative | Online Inquiry |
KO33323 | B4GALT6 Knockout cell line (A549) | Human | B4GALT6 | 1:3~1:4 | Negative | Online Inquiry |
B4GALT6 Gene Knockout Cell Lines are specialized cellular models designed to study the functional role of the B4GALT6 gene, which encodes a member of the beta-1,4-galactosyltransferase family involved in the biosynthesis of glycoproteins and glycolipids. By creating knockout variants of this gene, researchers can effectively investigate its contributions to various cellular processes, including glycan synthesis, cell signaling, and extracellular matrix organization.
The primary function of B4GALT6 Gene Knockout Cell Lines lies in the disruption of the B4GALT6 gene, leading to the absence of its corresponding protein product. This specific gene modification allows for comprehensive analyses of phenotypic changes, metabolic pathways, and potential compensatory mechanisms that elucidate the gene's role within the cell. Researchers can employ these knockout cells to delve into areas such as cell adhesion, migration, and differentiation, which are critical for understanding diseases such as cancer and developmental disorders.
In clinical and research settings, these cell lines serve as invaluable tools for drug development and target validation. By using B4GALT6 Gene Knockout Cell Lines, scientists can assess the effects of therapeutic compounds on cell behavior in a controlled environment. The insights gained contribute to the identification of new treatment strategies and biomarkers, enhancing our understanding of complex diseases.
What sets the B4GALT6 Gene Knockout Cell Lines apart from standard cell lines is their specificity and the thorough validation of the knockout status. These cell lines undergo rigorous quality control and characterization, ensuring the reliability of the experimental data derived from them. Their ability to model specific genetic conditions allows researchers to obtain high-fidelity results, addressing the translational gap seen in studies using traditional cell lines.
Investing in B4GALT6 Gene Knockout Cell Lines empowers researchers and clinicians alike to explore novel biological pathways and therapeutic avenues. By providing a robust and targeted research tool, we enable the advancement of science and medicine. Our company boasts extensive expertise in developing high-quality biological products, ensuring that our customers receive reliable and innovative solutions to meet their research needs.
Please note that all services are for research use only. Not intended for any clinical use.
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