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B4GALT2 Knockout Cell Lines

Gene: B4GALT2

Official Full Name: beta-1,4-galactosyltransferase 2provided by HGNC

Gene Summary: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02564 B4GALT2 Knockout cell line (HeLa) Human B4GALT2 1:3~1:6 Negative Online Inquiry
KO02565 B4GALT2 Knockout cell line (HCT 116) Human B4GALT2 1:2~1:4 Negative Online Inquiry
KO02566 B4GALT2 Knockout cell line (HEK293) Human B4GALT2 1:3~1:6 Negative Online Inquiry
KO02567 B4GALT2 Knockout cell line (A549) Human B4GALT2 1:3~1:4 Negative Online Inquiry

Background

B4GALT2 Gene Knockout Cell Lines are advanced cellular models engineered to permanently disable the B4GALT2 gene, which encodes for the enzyme β-1,4-galactosyltransferase 2. This enzyme plays a pivotal role in the biosynthesis of glycoproteins and glycolipids by facilitating the transfer of galactose to specific substrates, thereby significantly influencing cellular interactions, signaling pathways, and developmental processes. The knockout of this gene results in altered glycosylation patterns, allowing researchers to interrogate the functional implications of these changes in various biological systems.

These cell lines serve as essential tools in the study of carbohydrate biochemistry, cellular adhesion, and pathogen-host interactions. By utilizing B4GALT2 Gene Knockout Cell Lines, scientists can explore the gene's contributions to disease mechanisms, especially in cancer research, where glycan modifications often correlate with tumor progression and metastasis. Additionally, these models can aid in drug development efforts by providing insights into glycan-mediated drug targeting and resistance mechanisms.

What sets our B4GALT2 Gene Knockout Cell Lines apart from alternative products is the meticulous design validation and extensive characterization performed during development. Each cell line undergoes rigorous quality control to ensure consistent knockout efficiency and phenotypic stability, thereby guaranteeing reliability in experimental results. This high level of precision allows researchers to make confident conclusions based on their findings.

For researchers and clinicians focused on understanding the complexities of glycosylation and its effects on health and disease, the B4GALT2 Gene Knockout Cell Lines represent an invaluable resource. Their specialized application in both fundamental and applied sciences equips users with unique insights that can propel projects forward in significant ways. Our company is committed to advancing scientific knowledge and innovation, leveraging our expertise to provide high-quality biological products that meet the evolving needs of the research community.

Please note that all services are for research use only. Not intended for any clinical use.

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