Gene: B4GALNT3
Official Full Name: beta-1,4-N-acetyl-galactosaminyltransferase 3provided by HGNC
Gene Summary: B4GALNT3 transfers N-acetylgalactosamine (GalNAc) onto glucosyl residues to form N,N-prime-diacetyllactosediamine (LacdiNAc, or LDN), a unique terminal structure of cell surface N-glycans (Ikehara et al., 2006 [PubMed 16728562]).[supplied by OMIM, Aug 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO19501 | B4GALNT3 Knockout cell line (HCT 116) | Human | B4GALNT3 | 1:2~1:4 | Negative | Online Inquiry |
KO19502 | B4GALNT3 Knockout cell line (HEK293) | Human | B4GALNT3 | 1:3~1:6 | Negative | Online Inquiry |
B4GALNT3 Gene Knockout Cell Lines represent a powerful tool in genetic research, specifically designed to study the functional implications of the B4GALNT3 gene, which encodes for an enzyme involved in glycosylation processes essential for cellular signaling and adhesion. These cell lines have been meticulously engineered to lack functional copies of the B4GALNT3 gene, enabling researchers to elucidate the biological pathways and cellular processes influenced by this gene.
The primary mechanism of action of the B4GALNT3 gene knockout involves the disruption of the metabolic pathway responsible for the synthesis of glycoproteins and glycolipids. By studying these knockout cell lines, scientists can investigate how the absence of B4GALNT3 alters specific cellular functions, including cell proliferation, migration, and interaction with the extracellular matrix. Such insights are invaluable in understanding not only fundamental biology but also the mechanisms underlying various pathological conditions, including cancer and developmental disorders.
In terms of scientific importance, these cell lines can propel advances in both basic and applied research. They are beneficial in drug development studies where understanding the role of glycosylation in drug responsiveness is crucial. Additionally, they can serve as models for studying glycosylation-related diseases, facilitating the identification of potential biomarkers or therapeutic targets.
Compared to alternative models, including wild-type cells or less specific knockout systems, B4GALNT3 knockout cell lines provide precise control over the variable being studied. This specificity enhances the reliability of data derived from experiments, making it easier for researchers to draw clear conclusions regarding the gene’s role in health and disease.
Researchers and clinicians alike will find these cell lines invaluable, as they open avenues for novel discoveries and innovations in therapeutic strategies. The ability to manipulate these lines in the lab aligns perfectly with modern research initiatives focused on personalized medicine and biomolecular targeting.
At our company, we pride ourselves on offering high-quality, cutting-edge biological products, developed with the utmost precision and care. Our expertise in genetic engineering and deep commitment to advancing scientific research ensure that our B4GALNT3 Gene Knockout Cell Lines are not just products, but essential instruments for researchers aiming to deepen our understanding of genetic contributions to human health.
Please note that all services are for research use only. Not intended for any clinical use.
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