Home / B4GALNT2 Knockout Cell Lines

B4GALNT2 Knockout Cell Lines

Gene: B4GALNT2

Official Full Name: beta-1,4-N-acetyl-galactosaminyltransferase 2 (SID blood group)provided by HGNC

Gene Summary: B4GALNT2 catalyzes the last step in the biosynthesis of the human Sd(a) antigen through the addition of an N-acetylgalactosamine residue via a beta-1,4 linkage to a subterminal galactose residue substituted with an alpha-2,3-linked sialic acid. B4GALNT2 also catalyzes the last step in the biosynthesis of the Cad antigen (Montiel et al., 2003 [PubMed 12678917]).[supplied by OMIM, Mar 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27915 B4GALNT2 Knockout cell line (HEK293) Human B4GALNT2 1:3~1:6 Negative Online Inquiry
KO27916 B4GALNT2 Knockout cell line (A549) Human B4GALNT2 1:3~1:4 Negative Online Inquiry

Background

B4GALNT2 Gene Knockout Cell Lines are specialized cellular models that have undergone targeted gene disruption of the B4GALNT2 gene, which encodes an enzyme crucial for glycosylation processes—specifically, the synthesis of polysialic acid. By creating these knockout cell lines, researchers have the ability to investigate the functional role of B4GALNT2 in cellular processes including cell adhesion, migration, and signaling pathways, as well as its implications in developmental biology and certain disease states.

The mechanism behind the efficacy of these cell lines lies in their ability to mimic both physiological and pathological conditions with precision. In the absence of the B4GALNT2 gene, researchers can assess changes in cellular behaviors, gene expression profiles, and molecular interactions that are typically mediated by polysialylation. This offers a powerful insight into the enzyme's role in neurodevelopment and its potential contributions to conditions such as neurodegenerative diseases and cancer.

The scientific community recognizes the value of B4GALNT2 Gene Knockout Cell Lines as they provide a foundational platform for elucidating mechanisms underlying critical biological events. Their use facilitates advancements in drug development, gene therapy approaches, and cellular reprogramming studies, contributing to enhanced understanding of therapeutic targets.

What sets these knockout cell lines apart from other biological models is their specificity and ease of use. They eliminate the B4GALNT2 gene entirely, providing unparalleled clarity in experimental design, thus minimizing confounding factors that can arise in partial-knockdown models. Furthermore, these lines are rigorously validated for consistency, ensuring reproducible results across various experimental settings.

Researchers and clinicians will find immense value in incorporating B4GALNT2 Gene Knockout Cell Lines into their studies, particularly for those focused on gene function and therapeutic exploration related to glycosylation disorders. This product enhances the ability to develop targeted interventions while advancing the understanding of cellular dynamics reflective of real biological conditions.

At [Your Company Name], we pride ourselves on providing cutting-edge biological products and services backed by extensive expertise in genetic engineering and cell line development, ensuring that our clients receive only the most reliable tools for their research needs.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.