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B3GNT4 Knockout Cell Lines

Gene: B3GNT4

Official Full Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4provided by HGNC

Gene Summary: This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase protein family. The encoded enzyme is involved in the biosynthesis of poly-N-acetyllactosamine chains and prefers lacto-N-neotetraose as a substrate. It is a type II transmembrane protein. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19503 B3GNT4 Knockout cell line (HCT 116) Human B3GNT4 1:2~1:4 Negative Online Inquiry
KO19504 B3GNT4 Knockout cell line (HEK293) Human B3GNT4 1:3~1:6 Negative Online Inquiry

Background

B3GNT4 Gene Knockout Cell Lines are genetically engineered cellular models designed to elucidate the role of the B3GNT4 gene, primarily involved in glycosylation processes within mammalian cells. These cell lines have been created using advanced CRISPR-Cas9 gene-editing technology to specifically disrupt the B3GNT4 gene, thereby allowing researchers to investigate its functions and contributions to various biological pathways.

The primary function of the B3GNT4 gene is to encode a glycosyltransferase enzyme responsible for the addition of specific carbohydrate moieties to glycoproteins and glycolipids. Through these knockout models, researchers can study alterations in glycan structures affecting cell signaling, adhesion, and immune responses, which are critical for understanding many physiological and pathological conditions, including cancer progression and inflammatory diseases.

The scientific importance of B3GNT4 Gene Knockout Cell Lines is underscored by their broad applications in both basic research and clinical settings. They provide essential insights into glycobiology, enabling scientists to explore the implications of glycosylation in cell behavior, disease mechanisms, and therapeutic responses. Moreover, these cell lines can serve as vital tools for drug development, particularly in identifying potential targets for therapeutic intervention in diseases associated with glycosylation anomalies.

Compared to alternative models, such as wild-type cell lines or more generic knockout cells, B3GNT4 Gene Knockout Cell Lines offer a unique advantage by providing a controlled environment to specifically analyze the impacts of the B3GNT4 gene disruption. This specificity allows for more precise experimental outcomes and enhances the reliability of research findings.

For researchers, clinicians, and biopharmaceutical companies, the value of the B3GNT4 Gene Knockout Cell Lines lies in their ability to facilitate cutting-edge research and accelerate the discovery of novel therapeutic strategies. By integrating high-quality cellular models into their work, users can enhance their experimental rigor and extend the boundaries of current scientific knowledge.

Our company specializes in providing high-quality biological products tailored for innovative research and clinical applications. With extensive expertise in gene editing and cell line development, we are committed to supporting the scientific community with reliable and advanced tools, including our B3GNT4 Gene Knockout Cell Lines, to advance research and improve health outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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